Home / Proteasome Substrates / Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC)

Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC)

Catalog #: S-280
30 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
S-280-05M
Product Details
Citations (30)
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Reviews (1)
Summary Product Datasheets

Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC) Summary

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Citations for Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

30 Citations: Showing 1 - 10
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  1. An engineered cell line with a hRpn1-attached handle to isolate proteasomes
    Authors: Negi, H;Osei-Amponsa, V;Ibrahim, B;Evans, CN;Sullenberger, C;Loncarek, J;Chari, R;Walters, KJ;
    The Journal of biological chemistry  2023-06-22
  2. A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8
    Authors: KV Tarasov, K Chakir, DR Riordon, AE Lyashkov, I Ahmet, MG Perino, AJ Silvester, J Zhang, M Wang, YO Lukyanenko, JH Qu, MC Barrera, M Juhaszova, YS Tarasova, B Ziman, R Telljohann, V Kumar, M Ranek, J Lammons, R Bychkov, R de Cabo, S Jun, G Keceli, A Gupta, D Yang, MA Aon, L Adamo, CH Morrell, W Otu, C Carroll, S Chambers, N Paolocci, T Huynh, K Pacak, R Weiss, L Field, SJ Sollott, EG Lakatta
    Elife, 2022-12-14;11(0):.  2022-12-14
  3. Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells
    Authors: X Lan, M Hu, L Jiang, J Wang, Y Meng, X Chen, A Liu, W Ding, H Zhang, H Zhou, B Liu, G Peng, S Liao, X Chen, J Liu, X Shi
    Journal of ethnopharmacology, 2022-10-08;301(0):115815.  2022-10-08
  4. A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose
    Authors: D Sbardella, GR Tundo, A Mecchia, C Palumbo, MG Atzori, L Levati, A Boccaccini, AM Caccuri, P Cascio, PM Lacal, G Graziani, M Varano, M Coletta, M Parravano
    Cell & bioscience, 2022-07-16;12(1):108.  2022-07-16
  5. Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug
    Authors: GR Tundo, D Sbardella, F Oddone, G Grasso, S Marini, MG Atzori, AM Santoro, D Milardi, F Bellia, G Macari, G Graziani, F Polticelli, P Cascio, M Parravano, M Coletta
    Biomolecules, 2022-02-16;12(2):.  2022-02-16
  6. Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells
    Authors: M Benvenuto, S Ciuffa, C Focaccetti, D Sbardella, S Fazi, M Scimeca, GR Tundo, G Barillari, M Segni, E Bonanno, V Manzari, A Modesti, L Masuelli, M Coletta, R Bei
    Scientific Reports, 2021-09-24;11(1):19051.  2021-09-24
  7. Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition
    Authors: T Hirano, N Suzuki, Y Ikenaka, N Hoshi, Y Tabuchi
    Toxicology and Applied Pharmacology, 2021-09-11;430(0):115723.  2021-09-11
  8. PA28&alpha overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age
    Authors: J Adelöf, J Wiseman, M Zetterberg, M Hernebring
    Aging Cell, 2021-03-15;0(0):e13336.  2021-03-15
  9. Icariin Attenuates Amyloid-beta (Abeta)-Induced Neuronal Insulin Resistance Through PTEN Downregulation
    Authors: X Zou, X Feng, Y Fu, Y Zheng, M Ma, C Wang, Y Zhang
    Front Pharmacol, 2020-06-09;11(0):880.  2020-06-09
  10. Proteasome inhibition preserves longitudinal growth of denervated muscle and prevents neonatal neuromuscular contractures
    Authors: S Nikolaou, AA Cramer, L Hu, Q Goh, DP Millay, R Cornwall
    JCI Insight, 2019-12-05;0(0):.  2019-12-05
  11. The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity
    Authors: Y Heun, K Grundler G, K Pogoda, BF Kraemer, A Pfeifer, U Pohl, H Mannell
    Int J Mol Sci, 2019-09-07;20(18):.  2019-09-07
  12. An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes
    Authors: AA Nemec, AK Peterson, JL Warnock, RG Reed, RJ Tomko
    Cell Rep, 2019-01-08;26(2):483-495.e5.  2019-01-08
  13. Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy
    Authors: MA Kolpakov, K Sikder, A Sarkar, S Chaki, SK Shukla, X Guo, Z Qi, C Barbery, A Sabri, K Rafiq
    Cell. Physiol. Biochem., 2019-01-01;53(6):982-998.  2019-01-01
  14. A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growth
    Authors: X Li, Q Huang, H Long, P Zhang, H Su, J Liu
    EBioMedicine, 2018-12-05;0(0):.  2018-12-05
  15. Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating
    Authors: MR Eisele, RG Reed, T Rudack, A Schweitzer, F Beck, I Nagy, G Pfeifer, JM Plitzko, W Baumeister, RJ Tomko, E Sakata
    Cell Rep, 2018-07-31;24(5):1301-1315.e5.  2018-07-31
  16. YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity
    Authors: K Tanji, F Mori, Y Miki, J Utsumi, H Sasaki, A Kakita, H Takahashi, K Wakabayash
    Neurobiol. Dis., 2018-01-10;112(0):14-23.  2018-01-10
  17. Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells
    Authors: M Poletto, D Yang, SC Fletcher, I Vendrell, R Fischer, AJ Legrand, GL Dianov
    Nucleic Acids Res., 2017-09-29;45(17):10042-10055.  2017-09-29
  18. The Proteasome-Interacting Ecm29 Protein Disassembles the 26S Proteasome in Response to Oxidative Stress
    Authors: X Wang, IE Chemmama, C Yu, A Huszagh, Y Xu, R Viner, SA Block, P Cimermanci, SD Rychnovsky, Y Ye, A Sali, L Huang
    J. Biol. Chem., 2017-08-15;0(0):.  2017-08-15
  19. Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation
    Authors: X Lan, C Zhao, X Chen, P Zhang, D Zang, J Wu, J Chen, H Long, L Yang, H Huang, X Wang, X Shi, J Liu
    Cell Death Dis, 2017-07-06;8(7):e2913.  2017-07-06
  20. Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum
    Authors: M Ye, H Qiu, Y Cao, M Zhang, Y Mi
    Front. Pharmacol, 2017-03-21;8(0):148.  2017-03-21
  21. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice
    Proc. Natl. Acad. Sci. U.S.A, 2016-12-12;113(52):E8425-E8432.  2016-12-12
  22. The effect of temperature adaptation on the ubiquitin-proteasome pathway in notothenioid fishes
    Authors: Gretchen E Hofmann
    J. Exp. Biol., 2016-11-21;0(0):.  2016-11-21
  23. Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination
    Proc Natl Acad Sci USA, 2016-07-06;0(0):.  2016-07-06
  24. Clinical activity of carfilzomib correlates with inhibition of multiple proteasome subunits: application of a novel pharmacodynamic assay
    Authors: SJ Lee, K Levitsky, F Parlati, MK Bennett, S Arastu-Kap, L Kellerman, TF Woo, AF Wong, KP Papadopoul, R Niesvizky, AZ Badros, R Vij, S Jagannath, D Siegel, M Wang, GJ Ahmann, CJ Kirk
    Br J Haematol, 2016-04-12;0(0):.  2016-04-12
  25. Structure- and function-based design of Plasmodium-selective proteasome inhibitors.
    Authors: Li H, O'Donoghue A, van der Linden W, Xie S, Yoo E, Foe I, Tilley L, Craik C, da Fonseca P, Bogyo M
    Nature, 2016-02-11;530(7589):233-6.  2016-02-11
  26. Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction.
    Authors: Shanmugam, Mayilvah, Li, Dan, Gao, Shumin, Fefelova, Nadezhda, Shah, Vikas, Voit, Antanina, Pachon, Ronald, Yehia, Ghassan, Xie, Lai-Hua, Babu, Gopal J
    PLoS ONE, 2015-02-11;10(2):e0115822.  2015-02-11
  27. Inhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicity.
    Authors: Wang, Kun-Peng, Bai, Yu, Wang, Jian, Zhang, Jin-Zhen
    Mol Med Rep, 2014-03-04;9(5):1813-9.  2014-03-04
  28. Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.
    Authors: Cho, Kyoung-i, Patil, Hemangi, Senda, Eugene, Wang, Jessica, Yi, Haiqing, Qiu, Sunny, Yoon, Dosuk, Yu, Minzhong, Orry, Andrew, Peachey, Neal S, Ferreira, Paulo A
    J Biol Chem, 2014-01-08;289(8):4600-25.  2014-01-08
  29. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes.
    Authors: Kirk-Ballard, Heather, Wang, Zhong Q, Acharya, Priyanka, Zhang, Xian H, Yu, Yongmei, Kilroy, Gail, Ribnicky, David, Cefalu, William, Floyd, Z Elizab
    PLoS ONE, 2013-02-20;8(2):e57112.  2013-02-20
  30. Enzymatic discovery of a HER-2/neu epitope that generates cross-reactive T cells.
    Authors: Henle A, Erskine C, Benson L, Clynes R, Knutson K
    J Immunol, 2012-11-23;190(1):479-88.  2012-11-23

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Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC)
By TAKASHI SHIMADA on 05/02/2020

S-280 hydrolysis confirmation by LCMS-SRM
S-280: 1 uM
i20S: 15 nM
PA28a: 150 nM
Reaction: 37 °C for 5 h
1:S-280 Suc-LLVY-AMC (764.30>426.20)
2:Free AMC (176.25>120.00)
3:S-280 Suc-LLVY-COOH (607.35>426.20)

Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC) S-280