Home / Other Kinase Inhibitors / STOCK2S 26016

STOCK2S 26016

Catalog #: 5570
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5570/10
5570/50
STOCK2S 26016 | CAS No. 332922-63-1 | Other Kinase Inhibitors
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Description: Lysine deficient protein kinase (WNK) signaling inhibitor

Chemical Name: 7-Ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

STOCK2S 26016 is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively. Inhibits STK39 activation; inhibits migration and invasion of cancer cells in vitro.

Technical Data

M.Wt:
333.38
Formula:
C20H19N3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
332922-63-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for STOCK2S 26016

The citations listed below are publications that use Tocris products. Selected citations for STOCK2S 26016 include:

3 Citations: Showing 1 - 3

  1. OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection.
    Authors: Hortle Et al.
    Life Sci.Alliance  2022;5:e202201476
  2. STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation.
    Authors: Qiu Et al.
    Theranostics  2021;11:7658
  3. The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia.
    Authors: Lu Et al.
    Pflugers Arch.  2019;471:1539

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