ST 045849
Chemical Name: 2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid
Purity: ≥98%
Biological Activity
ST 045849 is an O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism.
Itkonen et al.
Oncotarget, 2016;7:12464 -
Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy.
Kim et al.
Sci.Rep., 2017;7:11107 -
Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors.
Kim et al.
Bioconjug.Chem., 2014;25:1025
Product Datasheets
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Citation for ST 045849
The citations listed below are publications that use Tocris products. Selected citations for ST 045849 include:
1 Citation: Showing 1 - 1
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O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis.
Authors: Edoardo Et al.
Nat Commun 2022;13:5212
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