Home / Adenylyl Cyclase Inhibitors / ST 034307

ST 034307

Catalog #: 6271
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6271/10
6271/50
ST 034307 | CAS No. 133406-29-8 | Adenylyl Cyclase Inhibitors
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Description: Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Technical Data

M.Wt:
297.95
Formula:
C10H4Cl4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
133406-29-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ST 034307

The citations listed below are publications that use Tocris products. Selected citations for ST 034307 include:

4 Citations: Showing 1 - 4

  1. Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice.
    Authors: Val J Et al.
    Front Pharmacol  2022;13:937741
  2. A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance.
    Authors: Giacoletti Et al.
    Front.Pharmacol.  2022;13:935588
  3. Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1.
    Authors: Bose Et al.
    BioRXiv - not yet peer reviewed  2021;
  4. Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats.
    Authors: Cheng Et al.
    Arch Oral Biol.  2019;98:81

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