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Src I1

Catalog #: 3642
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3642/10
3642/50
Src I1 | CAS No. 179248-59-0 | Src Family Kinase Inhibitors
1 Image
Description: Dual site Src kinase inhibitor

Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.

Technical Data

M.Wt:
373.4
Formula:
C22H19N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
179248-59-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.
    Leung W, Vong Q, Lin W, Bouck D, Wendt S, Sullivan E, Li Y, Bari R, Chen T, Leung W
    J Immunol, 2015;194(6):2930-41.
  2. The selectivity of protein kinase inhibitors: a further update.
    Bain et al.
    Biochem.J., 2007;408:297

Product Datasheets

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Reconstitution Calculator

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Citations for Src I1

The citations listed below are publications that use Tocris products. Selected citations for Src I1 include:

2 Citations: Showing 1 - 2

  1. CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.
    Authors: Zhang Et al.
    BMC Immunol  2019;20:7
  2. PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.
    Authors: Leung Et al.
    J Immunol  2015;194:2930

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