SR 9009
Chemical Name: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Purity: ≥98%
Biological Activity
SR 9009 is a Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.
Shin et al.
Bioorg.Med.Chem.Lett., 2012;22:4413 -
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
Solt et al.
Nature, 2012;485:62
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Citation for SR 9009
The citations listed below are publications that use Tocris products. Selected citations for SR 9009 include:
1 Citation: Showing 1 - 1
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Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.
Authors: Hanne M Et al.
Sci Rep 2022;12:17856
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