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SR 11302

Catalog #: 2476
26 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2476/10
SR 11302 | CAS No. 160162-42-5 | AP-1 Inhibitors
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Description: AP-1 inhibitor; antitumor agent

Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid

Purity: ≥98%

Product Details
Citations (26)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).

Technical Data

M.Wt:
376.54
Formula:
C26H32O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
160162-42-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor kappaB in BEAS-2B cells.
    O'Sullivan M, Hirota N, Martin J
    PLoS ONE, 2014;9(4):e95566.
  2. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells
    C Kim, B Hu, RR Jadhav, J Jin, H Zhang, MM Cavanagh, RS Akondy, R Ahmed, CM Weyand, JJ Goronzy
    Cell Rep, 2018;25(8):2148-2162.e5.
  3. Tumour necrosis factor-alpha regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kappaB and AP-1.
    Kankaanranta H, Ilmarinen P, Zhang X, Adcock I, Lahti A, Barnes P, Giembycz M, Lindsay M, Moilanen E
    PLoS ONE, 2014;9(2):e90298.
  4. Induction of TNF, CXCL8 and IL-1? in macrophages by Helicobacter pylori secreted protein HP1173 occurs via MAP-kinases, NF-?B and AP-1 signaling pathways
    R Tavares, SK Pathak
    Microb. Pathog., 2018;0(0):.
  5. Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury.
    Qi W, Li H, Cai X, Gu J, Meng J, Xie H, Zhang J, Chen J, Jin X, Tang Q, Hao Y, Gao Y, Wen A, Xue X, Gao Smith F, Jin S
    Lab Invest, 2015;95(11):1258-68.
  6. Microbial Antigens Stimulate Metalloprotease-7 Secretion in Human B-Lymphocytes Using mTOR-Dependent and Independent Pathways
    MF Ali, H Dasari, VP Van Keulen, D Cornec, G Vasmatzis, T Peikert, EM Carmona
    Sci Rep, 2017;7(1):3869.
  7. Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.
    Shiohara et al.
    Blood, 1999;93:2057
  8. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
    Huang et al.
    Proc.Natl.Acad.Sci.USA, 1997;94:5826
  9. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation.
    Fanjul et al.
    Nature, 1994;372:107
  10. Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells
    H Kuramoto, K Hirao, H Yumoto, Y Hosokawa, T Nakanishi, D Takegawa, A Washio, C Kitamura, T Matsuo
    Biomed Res Int, 2019;2019(0):5390720.
  11. Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress
    J Chung, KH Kim, SH An, S Lee, BK Lim, SW Kang, K Kwon
    Exp. Mol. Med., 2019;51(11):144.

Product Datasheets

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Citations for SR 11302

The citations listed below are publications that use Tocris products. Selected citations for SR 11302 include:

26 Citations: Showing 1 - 10

  1. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
    Authors: Martin-Gallausiaux Et al.
    Front Immunol  2019;9:2838
  2. IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin.
    Authors: Bawazeer and Theoharides
    Eur J Pharmacol  2019;865
  3. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
    Authors: Messerschmidt Et al.
    Mol Vis  2019;25:329
  4. TGF-β1 expression in regulatory NK1.1-CD4+NKG2D+ T cells dependents on the PI3K-p85α/JNK, NF-κB and STAT3 pathways.
    Authors: Han Et al.
    Am J Cancer Res  2018;8:489
  5. Elevated sodium chloride drives type I IF. signaling in macrophages and increases antiviral resistance.
    Authors: Zhang Et al.
    J Biol Chem  2018;293:1030
  6. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.
    Authors: Kim Et al.
    Cell Rep  2018;25:2148
  7. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  8. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos.
    Authors: Sun Et al.
    J Exp Med  2017;214:1753
  9. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium.
    Authors: Bugel Et al.
    Toxicol Appl Pharmacol  2016;296:31
  10. Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-& #954;B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II.
    Authors: Lee Et al.
    PLoS One  2016;11:e0163415
  11. Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression.
    Authors: Lee Et al.
    Oncotarget  2015;6:22139
  12. The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization.
    Authors: Zheng Et al.
    Invest Ophthalmol Vis Sci  2015;5:14408
  13. p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation.
    Authors: Huang Et al.
    Int J Gynecol Cancer  2015;3:225
  14. Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway.
    Authors: Chen Et al.
    Sci Rep  2015;25:953
  15. Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.
    Authors: Nadeau-Vall&eacutee Et al.
    J Immunol  2015;195:3402
  16. NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.
    Authors: Banskota Et al.
    Mol Cancer  2015;14:123
  17. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
    Authors: Oruqaj Et al.
    Proc Natl Acad Sci U S A  2015;112:E2048
  18. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells.
    Authors: O'Sullivan Et al.
    PLoS One  2014;9:e95566
  19. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
    Authors: Pernet Et al.
    Nat Commun  2014;5:5105
  20. Self-priming determines high type I IFN production by plasmacytoid dendritic cells.
    Authors: Kim Et al.
    Eur J Immunol  2014;44:807
  21. Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells.
    Authors: Mason Et al.
    Drug Metab Dispos  2014;42:2077
  22. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
    Authors: Bakhru Et al.
    Cell Immunol  2014;287:53
  23. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem  2013;288:27519
  24. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal  2013;11:35
  25. Transforming growth factor-β induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells.
    Authors: Sethi Et al.
    PLoS One  2011;52:5240
  26. Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
    Authors: Ivanova Et al.
    FASEB J  2011;25:1402

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