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Squarunkin A hydrochloride

Catalog #: 6364 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6364/50
6364/10
Squarunkin A hydrochloride | CAS No. 2253744-55-5 | Src Family Kinase Inhibitors
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Description: UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation

Chemical Name: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride

Purity: ≥98%

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Biological Activity

Squarunkin A hydrochloride is a potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.

Technical Data

M.Wt:
560.01
Formula:
C25H32F3N5O4.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2253744-55-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule inhibition of the UNC119-cargo interaction.
    Mejuch et al.
    Angew.Chem.Int.Ed., 2017;56:6181

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