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Spironolactone

Catalog #: 2968
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2968/50
Spironolactone | CAS No. 52-01-7 | Mineralocorticoid Receptor Antagonists
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Description: Mineralocorticoid receptor antagonist
Alternative Names: SC 9420,Aldactone

Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Technical Data

M.Wt:
416.57
Formula:
C24H32O4S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
52-01-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Spironolactone, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Spironolactone

The citations listed below are publications that use Tocris products. Selected citations for Spironolactone include:

3 Citations: Showing 1 - 3

  1. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.
    Authors: Pinheiro Et al.
    Brain Res Bull  2016;124:222
  2. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain  2014;7:32
  3. Effects of acute restraint stress on set-shifting and reversal learning in male rats.
    Authors: Thai Et al.
    Cogn Affect Behav Neurosci  2013;13:164

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