Sphingosine-1-phosphate
Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol
Purity: ≥98%
Biological Activity
Sphingosine-1-phosphate is an endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. Also activates VRAC-mediated transport of 2'3'-cyclic-GMP-AMP (cGAMP).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P).
Williams P, Stilhano R, To V, Tran L, Wong K, Silva E
PLoS ONE, 2015;10(4):e0123437. -
Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells.
Essler et al.
Cell.Signal., 2002;14:607 -
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
Pyne and Pyne
Pharmacol.Ther., 2000;88:115 -
Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Uhlenbrock et al.
Cell.Signal., 2002;14:941 -
Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate.
van Koppen et al.
J.Biol.Chem., 1996;271:2082 -
Optical control of sphingosine-1-phosphate formation and function.
Morstein et al.
Nat.Chem, 2019;15:623 -
LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP.
Lahey et al.
Mol.Cell., 2020;80:1 -
PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity
ED Lucas, JB Schafer, J Matsuda, M Kraus, MA Burchill, BAJ Tamburini
Cell Rep, 2020;33(2):108258.
Product Datasheets
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Citations for Sphingosine-1-phosphate
The citations listed below are publications that use Tocris products. Selected citations for Sphingosine-1-phosphate include:
10 Citations: Showing 1 - 10
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Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Authors: H?bner Et al.
Nat Commun 2018;9:4860
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The signaling lipid sphingosine 1-phosphate regulates mechanical pain.
Authors: Hill Et al.
Elife 2018;7
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Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.
Authors: Krispin Et al.
Arterioscler Thromb Vasc Biol 2018;38:353
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Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Authors: Simula Et al.
Cell Rep 2018;25:3059
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Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development.
Authors: Hu Et al.
J Am Soc Nephrol 2016;27:1984
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Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
Authors: Camp Et al.
Pharmacol Res 2016;105:13
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Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.
Authors: Kho Et al.
Mol Pain 2015;5:199
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Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
Authors: Evseenko Et al.
PLoS One 2013;8:e63718
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Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
Authors: Hannedouche Et al.
Biosensors (Basel) 2013;288:27434
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PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
Authors: Pierre Et al.
EMBO J 2004;23:3031
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