Sodium butyrate

Biological Activity

Sodium butyrate is a histone deacetylase inhibitor (HDAC). Sodium butyrate restores contextual memory in a transgenic mouse model of Alzheimer's disease. In a transgenic mouse model of Huntington's disease, sodium butyrate ameliorates the neurodegenerative phenotype and extends survival. Sodium butyrate induces pancreatic progenitor formation, and directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Sodium butyrate also augments transcription factor stimulated iPSC generation. In hepatocellular carcinoma cells, Sodium butyrate downregulates expression of c-Myc resulting in decreased hexokinase 2 levels, inhibition of aerobic glycolysis and reduced cell growth.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Butyrate promotes induced pluripotent stem cell generation.
   Liang et al.
   J.Biol.Chem., 2010;285:25516
2. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.
   Boffa et al.
   J.Biol.Chem., 1978;253:3364
3. Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease.
   Kilgore et al.
   Neuropsychopharmacology, 2010;35:870
4. Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells.
   Ren et al.
   J.Cell Biochem., 2010;109:236
5. Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.
   Zhou et al.
   J.Cell Biochem., 2010;109:606

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