Simple Plex Mouse/Rat Osteopontin/OPN Cartridge
Simple Plex Mouse/Rat Osteopontin/OPN Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Product Summary
Precision
Rat EDTA Plasma, Heparin Plasma, Mouse Urine, Rat Urine, Cerebrospinal Fluid
Intra-Assay Precision | Inter-Assay Precision |
---|---|
Sample | 1 |
n | 16 |
Mean (pg/mL) | 24.7 |
Standard Deviation | 1.03 |
CV% | 4.2 |
Recovery
Recovery at three different spiked concentrations within the range of the assay was evaluated.
Sample Type | Average % Recovery | Range % |
---|---|---|
Urine (n=4) | 108 | 96-120 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: Osteopontin/OPN
Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad¬hesion, and migration. Its expression is upregulat¬ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.
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