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Sildenafil citrate

Catalog #: 3784
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3784/25
3784/5
Sildenafil citrate | CAS No. 171599-83-0 | Phosphodiesterase Inhibitors
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Description: Potent PDE5 inhibitor; orally active

Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

Sildenafil citrate is an orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.

Technical Data

M.Wt:
666.7
Formula:
C22H30N6O4S.C6H8O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
171599-83-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Sildenafil citrate

The citations listed below are publications that use Tocris products. Selected citations for Sildenafil citrate include:

2 Citations: Showing 1 - 2

  1. Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage.
    Authors: Xiaofeng Et al.
    Cell Chem Biol  2021;28:1669-1678.e5
  2. The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems.
    Authors: Vandendriessche Et al.
    Development  2013;8:e72155

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