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SI-2 hydrochloride

Catalog #: 5964
1 Citation Datasheet / COA / SDS
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5964/10
5964/50
SI-2 hydrochloride | CAS No. 1992052-49-9 | Additional Nuclear Receptor Compounds
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Description: Steroid receptor coactivator 3 (SRC-3) inhibitor

Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Technical Data

M.Wt:
301.78
Formula:
C15H15N5.HCl
Solubility:
Soluble to 50 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1992052-49-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.
    Song et al.
    Proc.Natl.Acad.Sci.U.S.A., 2016;113:4970

Product Datasheets

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Citation for SI-2 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SI-2 hydrochloride include:

1 Citation: Showing 1 - 1

  1. SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning.
    Authors: Wei Et al.
    J Biol Chem  2021;297:101044

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