SHA 68
Chemical Name: N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
Purity: ≥98%
Biological Activity
SHA 68 is a selective neuropeptide S receptor (NPSR) antagonist (IC50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain.
Okamura et al.
Neuropsychopharmacology, 2011;36:744 -
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).
Trapella et al.
J.Med.Chem., 2011;54:2738 -
Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.
Okamura et al.
J.Pharmacol.Exp.Ther., 2008;325:893
Product Datasheets
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Citations for SHA 68
The citations listed below are publications that use Tocris products. Selected citations for SHA 68 include:
2 Citations: Showing 1 - 2
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Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory.
Authors: Jing Et al.
Chem Senses 2020;45:195-202
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Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies.
Authors: Ruzza Et al.
Pharmacol Res Perspect 2018;6:e00445
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