SF 1670

Catalog #: 5020
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5020/10
5020/50

SF 1670 | CAS No. 345630-40-2 | Protein Tyrosine Phosphatase Inhibitors

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Description: PTPN2 and PTEN inhibitor

Alternative Names: PTP Inhibitor XIX

Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide

Purity: ≥98%

View All Products for Protein Tyrosine Phosphatase Inhibitors

Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SF 1670 is a PTPN2 and PTEN inhibitor (IC₅₀values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP₃ signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

Technical Data

M.Wt:

307.34

Formula:

C₁₉H₁₇NO₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

345630-40-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor.
Le et al.
BMB Rep., 2017;50:329
Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model.
Li
Blood, 2011;117:6702

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SF 1670

The citations listed below are publications that use Tocris products. Selected citations for SF 1670 include:

2 Citations: Showing 1 - 2

TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22.
Authors: Gail A Et al.
Sci Signal 2022;15:eabn5507
Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity.
Authors: Lei Et al.
J Cell Biol 2017;216:2551

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