SD 2590 hydrochloride

Catalog #: 4775 Datasheet / COA / SDS

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SD 2590 hydrochloride | CAS No. 226395-93-3 | Synthetic Metalloprotease Inhibitors

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Description: Potent MMP inhibitor

Alternative Names: SC 78080

Chemical Name: N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SD 2590 hydrochloride is a potent MMP inhibitor (IC₅₀ values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.

Technical Data

M.Wt:

554.96

Formula:

C₂₂H₂₅F₃N₂O₇S.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

226395-93-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from Pfizer Inc

Background References

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
Becker et al.
J.Med.Chem., 2010;53:6653

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