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SD 1008

Catalog #: 3035 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3035/10
3035/50
SD 1008 | CAS No. 960201-81-4 | STAT Inhibitors
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Description: JAK2/STAT3 signaling pathway inhibitor

Chemical Name: (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester

Purity: ≥99%

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Biological Activity

SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Technical Data

M.Wt:
329.35
Formula:
C18H19NO5
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
960201-81-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Direct regulation of the proglucagon gene by insulin, leptin, and cAMP in embryonic versus adult hypothalamic neurons.

    Mol. Endocrinol., 2102;26(8):1339-55.
  2. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.
    Duan et al.
    Mol.Pharmacol., 2007;72:1137
  3. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
    SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry
    Cell Rep, 2020;31(1):107472.

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