SB 204741
Chemical Name: N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea
Purity: ≥99%
Biological Activity
SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease.
Ebrahimkhani et al.
Nat.Med., 2011;17:1668 -
N-(1-Methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist.
Forbes et al.
J.Med.Chem., 1995;38:855 -
The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors.
Bonhaus et al.
Br.J.Pharmacol., 1995;115:622 -
Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors.
Glusa and Pertz
Br.J.Pharmacol., 2000;130:692
Product Datasheets
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Citations for SB 204741
The citations listed below are publications that use Tocris products. Selected citations for SB 204741 include:
7 Citations: Showing 1 - 7
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Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
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Serotonin Improves High Fat Diet Induced Obesity in Mice.
Authors: Watanabe Et al.
PLoS One 2016;11:e0147143
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Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca2+-activated chloride channels.
Authors: Salzer Et al.
Neuropharmacology 2016;110 (A):277
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Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
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Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.
Authors: Hernandez Et al.
BMC Complement Altern Med 2012;302:E1009
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Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B.
Authors: Wouters Et al.
J Biol Chem 2009;284:21177
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
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