Saxagliptin hydrochloride

Catalog #: 6507 Datasheet / COA / SDS

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Saxagliptin hydrochloride | CAS No. 709031-78-7 | DPPIV/CD26 Inhibitors

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Description: High affinity DPP-IV inhibitor; active in vivo

Alternative Names: BMS 477118

Chemical Name: (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride

Purity: ≥98%

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Biological Activity

Saxagliptin hydrochloride is a high affinity DPP-IV inhibitor (K_i = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zucker^fa/fa rats.

Technical Data

M.Wt:

351.87

Formula:

C₁₈H₂₅N₃O₂.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

709031-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery and preclinical profile of saxagl. (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Augeri et al.
J.Med.Chem., 2005;48:5025

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