Sarafotoxin S6c

Name: Sarafotoxin S6c
Brand: Tocris Bioscience
SKU: 1175
Price: 258 USD

Catalog #: 1175
2 Citations Datasheet / COA / SDS

Discontinued Product

1175 has been discontinued.

View all Endothelin ETB Receptor Agonists products.

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Description: Selective ETB agonist

Purity: ≥95%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sarafotoxin S6c is a highly selective ET_B endothelin receptor agonist (K_i values are 0.29 and 28000 nM at ET_B and ET_A receptors respectively).

Technical Data

M.Wt:

2516

Formula:

C₁₀₃H₁₄₇N₂₇O₃₇S₅

Sequence:

CTCNDMTDEECLNFCHQDVIW

(Modifications: Disulfide bridges: 1-15, 3-11)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

121695-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Tachykinins stimulate a subset of mouse taste cells.
,,
PLoS ONE, 2012;7(2):e31697.
Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum.
Miasiro et al.
J.Cardiovasc.Pharmacol., 1998;31:S175
Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs.
Matsuo et al.
J.Pharmacol.Exp.Ther., 1997;280:905
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes.
Williams et al.
Biochem.Biophys.Res.Commun., 1991;175:556
Characterization of cloned human endothelin receptors.
Williams et al.
Life Sci., 1993;53:407

Product Datasheets

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Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Sarafotoxin S6c

The citations listed below are publications that use Tocris products. Selected citations for Sarafotoxin S6c include:

2 Citations: Showing 1 - 2

Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats.
Authors: Ou Et al.
J Cell Physiol 2014;229:489
Functional and molecular characterization of the endothelin system in retinal arterioles.
Authors: Hein Et al.
Br J Pharmacol 2009;50:3329

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