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Sanguinarine chloride

Catalog #: 2302
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2302/5
2302/25
Sanguinarine chloride | CAS No. 5578-73-4 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Inhibitor of protein phosphatase 2C (PP2C)

Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride

Purity: ≥97%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.

Technical Data

M.Wt:
367.78
Formula:
C20H14ClNO4
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
5578-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.
    Candas D, Lu C, Fan M, Chuang F, Sweeney C, Borowsky A, Li J
    Cancer Res, 2014;74(24):7498-509.
  2. The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1.
    Vogt et al.
    J.Biol.Chem., 2005;280:19078
  3. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.
    Aburai et al.
    Biosci.Biotechnol.Biochem., 2010;74:548
  4. Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
    Adhami et al.
    Mol.Cell Ther., 2004;3:934

Product Datasheets

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Citations for Sanguinarine chloride

The citations listed below are publications that use Tocris products. Selected citations for Sanguinarine chloride include:

4 Citations: Showing 1 - 4

  1. Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.
    Authors: Pereira Et al.
    Cell Rep  2018;23:1124
  2. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
    Authors: Kenny Et al.
    PLoS One  2015;6:6220
  3. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.
    Authors: Candas Et al.
    Cancer Res  2014;74:7498
  4. The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis.
    Authors: Bavaria Et al.
    Apoptosis  2014;19:467

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