Salmeterol xinafoate
Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt
Purity: ≥99%
Biological Activity
Salmeterol xinafoate is a long-acting β2 adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D2, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neuroendocrine Modulation of IL-27 in Macrophages
J Roewe, M Higer, DR Riehl, A Gericke, MP Radsak, M Bosmann
J. Immunol., 2017;0(0):. -
ASM-024, a piperazinium compound, promotes the in vitro relaxation of beta2-adrenoreceptor desensitized tracheas.
Israel-Assayag E, Beaulieu M, Cormier Y
PLoS ONE, 2015;10(3):e0120095. -
Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells.
Akabane et al.
Allergol.Int., 2006;55:387 -
Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease.
Rennard et al.
Am.J.Respir.Crit.Care Med., 2001;163:1087 -
The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma.
Roberts et al.
Eur.Respir.J., 1999;14:275 -
Effects of salme. xinafoate and flutic. propionate on immunological activation of human cultured mast cells.
Akabane et al.
Allergol.Int., 2006;55:387 -
Use of a long-acting inhaled beta2-adrenergic agonist, salme. xinafoate, in patients with chronic obstructive pulmonary disease.
Rennard et al.
Am.J.Respir.Crit.Care Med., 2001;163:1087 -
The long-acting beta2-agonist salme. xinafoate: effects on airway inflammation in asthma.
Roberts et al.
Eur.Respir.J., 1999;14:275
Product Datasheets
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Citations for Salmeterol xinafoate
The citations listed below are publications that use Tocris products. Selected citations for Salmeterol xinafoate include:
8 Citations: Showing 1 - 8
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The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.
Authors: Pon Et al.
FASEB J 2016;30:1144
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ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas.
Authors: Israël-Assayag Et al.
Nat Commun 2015;10:e0120095
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Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
Authors: Zaytseva Et al.
Sens Actuators B Chem 2013;188
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Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists.
Authors: Sykes and Charlton
Br J Pharmacol 2012;165:2672
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Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Authors: Rankovic Et al.
PLoS One 2011;6:e27474
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The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells.
Authors: Scola Et al.
Br J Pharmacol 2009;158:267
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Effect of indacaterol, a novel long-acting beta2-agonist, on isolated human bronchi.
Authors: C Et al.
Eur Respir J 2007;29:575-81
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Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
Authors: Nackley Et al.
Pain 2007;128:199
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