(S)-(-)-Pindolol

Name: ( S )-(-)-Pindolol
Brand: Tocris Bioscience
SKU: 1060
Price: 280 USD

Catalog #: 1060
1 Citation Datasheet / COA / SDS

Discontinued Product

1060 has been discontinued.

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(S)-(-)-Pindolol | CAS No. 26328-11-0 | Adrenergic beta-3 Receptor Agonists

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Description: β3 partial agonist; also 5-HT1A and 5-HT1B antagonist; more active enantiomer of pindolol (Cat. No. 0994)

Chemical Name: (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

Purity: ≥99%

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Product Details

Citations (1)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(S)-(-)-Pindolol is a 5-HT_1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β₃-adrenoceptors. More active enantiomer of pindolol.

Racemate also available.

Technical Data

M.Wt:

248.32

Formula:

C₁₄H₂₀N₂O₂

Solubility:

Soluble to 100 mM in 1eq. HCl

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

26328-11-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Racemate Available

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT_1A receptors in the rat brain.
Corradetti et al.
Br.J.Pharmacol., 1998;123:449
β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT_1A receptor agonists.
Kalkman
Eur.J.Pharmacol., 1989;173:121
Stimulant and blocking effects of optical isomers of pin. on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation.
Walter et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1984;327:159

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for (S)-(-)-Pindolol

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Pindolol include:

1 Citation: Showing 1 - 1

Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
Authors: Kaya Et al.
Front Neurosci 2009;329:350

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