(S)-3,4-DCPG

Biological Activity

Caged (S)-3,4-DCPG, Racemate and R-enantiomer also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.
   Moldrich et al.
   Neuropharmacology, 2001;40:732
3. Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice.
   Linden et al.
   Neuropharmacology, 2003;45:473
4. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
   Thomas et al.
   Eur.J.Pharmacol., 1997;338:111
5. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
   Thomas et al.
   Neuropharmacology, 2001;40:311

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