(RS)-(±)-Sulpiride

Catalog #: 0894
7 Citations Datasheet / COA / SDS

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(RS)-(±)-Sulpiride | CAS No. 15676-16-1 | Non-selective Dopamine Receptor Antagonists

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Description: Standard selective D2-like antagonist

Chemical Name: (RS)-(±)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide

Purity: ≥98%

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Product Details

Citations (7)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(RS)-(±)-Sulpiride is a standard D₂-like dopamine receptor antagonist.

S-enantiomer also available.

Technical Data

M.Wt:

341.42

Formula:

C₁₅H₂₃N₃O₄S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

15676-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

S-enantiomer Available

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
DA D₄ receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.
Seeman and Van Tol
Eur.J.Pharmacol., 1993;233:173

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Citations for (RS)-(±)-Sulpiride

The citations listed below are publications that use Tocris products. Selected citations for (RS)-(±)-Sulpiride include:

7 Citations: Showing 1 - 7

DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice.
Authors: Huang
Invest Ophthalmol Vis Sci 2018;59(6):2623
DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
Authors: Zhang Et al.
Invest Ophthalmol Vis Sci 2018;59(11):4441
Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
Authors: Leyrer-Jackson
Physiol Rep 2017;5(22):e13499
Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues.
Authors: Holroyd Et al.
Brain 2015;40:1495
Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians.
Authors: Zhang Et al.
Physiol Behav 2013;112-113:8
Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of DArgic d1 receptor.
Authors: Shin Et al.
Neuropsychopharmacology 2011;20:130

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