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RS 39604 hydrochloride

Catalog #: 0991
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0991/10
0991/50
RS 39604 hydrochloride | CAS No. 167710-87-4 | 5-HT4 Receptor Antagonists
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Description: 5-HT4 antagonist

Chemical Name: 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.

Technical Data

M.Wt:
590.56
Formula:
C26H36ClN3O6S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
167710-87-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Roche Bioscience

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Central 5-HT4 receptors
    Eglen et al.
    TiPS, 1995;16:391
  3. RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist.
    Hegde
    Br.J.Pharmacol., 1995;115:1087

Product Datasheets

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Citations for RS 39604 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for RS 39604 hydrochloride include:

3 Citations: Showing 1 - 3

  1. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
    Authors: Ratner Et al.
    Learn Mem  2012;20:2133
  2. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453
  3. Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis.
    Authors: Huang and Kandel
    J Pharmacol Exp Ther  2007;14:497

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