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Recombinant Mouse IFN-alpha A Protein

Catalog #: 12100-1
25 Citations Datasheet / COA / SDS
Newer Version Available: 10150-IF
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A New rmIFN-alpha A is Available! It is mammalian cell derived, has lower endotoxin specifications, is made in-house, and is priced competitively!
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12100-1
R&D Systems Recombinant Proteins and Enzymes
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Citations (25)
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Recombinant Mouse IFN-alpha A Protein Summary

Product Specifications

Accession #
NP_996753

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12100-1

Product Datasheet
COA
SDS

12100-1

Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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Background: IFN-alpha 2/IFNA2

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name
Interferon alpha 2
Entrez Gene IDs
3440 (Human); 15965 (Mouse); 298213 (Rat)
Alternate Names
alpha-2a interferon; Ifa2; IFNA; IFNA2; IFNA2a; IFNA2b; IFNA2c; IFNAA; IFNalpha 2; IFN-alpha 2; IFN-alpha-2; IFN-alphaA; INFA2; interferon alpha 2b; interferon alpha A; interferon alpha-2; Interferon alpha-A; interferon, alpha 2; LeIF A; MGC125764; MGC125765

Citations for Recombinant Mouse IFN-alpha A Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

25 Citations: Showing 1 - 10
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  1. A sensitive assay for measuring whole-blood responses to type I IFNs
    Authors: Gervais, A;Le Floc'h, C;Le Voyer, T;Bizien, L;Bohlen, J;Celmeli, F;Al Qureshah, F;Masson, C;Rosain, J;Chbihi, M;Lévy, R;Castagnoli, R;Rothenbuhler, A;Jouanguy, E;Zhang, Q;Zhang, SY;Béziat, V;Bustamante, J;Puel, A;Bastard, P;Casanova, JL;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
    Authors: L Yang, S Chen, Q Zhao, C Pan, L Peng, Y Han, L Li, J Ruan, J Xia, H Yang, F Xu, G Cheng
    Cell Reports, 2022-01-25;38(4):110302.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. The innate immunity protein IFITM3 modulates &gamma-secretase in Alzheimer's disease
    Authors: JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, Y Zhai, JC Wang, J Tcw, L Guo, A McKenzie, C Ming, X Zhou, M Wang, Y Sagi, AE Renton, BT Esposito, Y Kim, KR Sadleir, I Trinh, RA Rissman, R Vassar, B Zhang, DS Johnson, E Masliah, P Greengard, A Goate, YM Li
    Nature, 2020-09-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment
    Authors: C Ge, IR Monk, A Pizzolla, N Wang, JG Bedford, TP Stinear, GP Westall, LM Wakim
    Cell Rep, 2019-12-24;29(13):4236-4244.e3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  5. Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
    Authors: K Haruwaka, A Ikegami, Y Tachibana, N Ohno, H Konishi, A Hashimoto, M Matsumoto, D Kato, R Ono, H Kiyama, AJ Moorhouse, J Nabekura, H Wake
    Nat Commun, 2019-12-20;10(1):5816.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  6. The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
    Authors: Y Zhang, F Thery, NC Wu, EK Luhmann, O Dussurget, M Foecke, C Bredow, D Jiménez-Fe, K Leandro, A Beling, KP Knobeloch, F Impens, P Cossart, L Radoshevic
    Nat Commun, 2019-11-26;10(1):5383.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  7. ImmGen report: sexual dimorphism in the immune system transcriptome
    Authors: ST Gal-Oz, B Maier, H Yoshida, K Seddu, N Elbaz, C Czysz, O Zuk, BE Stranger, H Ner-Gaon, T Shay
    Nat Commun, 2019-09-20;10(1):4295.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  8. Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
    Authors: W Li, G Feng, JM Gauthier, I Lokshina, R Higashikub, S Evans, X Liu, A Hassan, S Tanaka, M Cicka, HM Hsiao, D Ruiz-Perez, A Bredemeyer, RW Gross, DL Mann, YY Tyurina, AE Gelman, VE Kagan, A Linkermann, KJ Lavine, D Kreisel
    J. Clin. Invest., 2019-02-26;130(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  9. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
    Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
    J. Immunol., 2017-06-02;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Bioassay
  10. Network pharmacology of JAK inhibitors
    Proc Natl Acad Sci USA, 2016-08-11;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence
    PLoS ONE, 2016-05-19;11(5):e0155947.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  12. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells
    Authors: P Shou, Q Chen, J Jiang, C Xu, J Zhang, C Zheng, M Jiang, T Velletri, W Cao, Y Huang, Q Yang, X Han, L Zhang, L Wei, AB Rabson, YE Chin, Y Wang, Y Shi
    Oncogene, 2016-04-25;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. ATF3 Is a Key Regulator of Macrophage IFN Responses.
    Authors: Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D
    J Immunol, 2015-09-28;195(9):4446-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Tumor Progression Locus 2 Promotes Induction of IFNlambda, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus.
    Authors: Kuriakose T, Tripp R, Watford W
    PLoS Pathog, 2015-08-04;11(8):e1005038.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. USP18 is crucial for IFN-gamma-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.
    Authors: Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian J, Yi Q
    Mol Cancer, 2014-05-31;13(0):132.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Corepressor Rcor1 is essential for murine erythropoiesis.
    Authors: Yao H, Goldman D, Nechiporuk T, Kawane S, McWeeney S, Tyner J, Fan G, Kerenyi M, Orkin S, Fleming W, Mandel G
    Blood, 2014-03-20;123(20):3175-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. A role for the ITAM signaling module in specifying cytokine-receptor functions.
    Authors: Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R
    Nat Immunol, 2014-03-09;15(4):333-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
    Authors: Bosmann M, Strobl B, Kichler N, Rigler D, Grailer J, Pache F, Murray P, Muller M, Ward P
    J Leukoc Biol, 2014-03-06;96(1):123-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
    Authors: Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K
    Proc Natl Acad Sci U S A, 2014-01-27;111(8):3068-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. The exonuclease Trex1 restrains macrophage proinflammatory activation.
    Authors: Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A
    J Immunol, 2013-11-11;191(12):6128-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
    Authors: Kerenyi, Marc A, Shao, Zhen, Hsu, Yu-Jung, Guo, Guoji, Luc, Sidinh, O'Brien, Kassandr, Fujiwara, Yuko, Peng, Cong, Nguyen, Minh, Orkin, Stuart H
    Elife, 2013-06-18;2(0):e00633.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
    Authors: Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R
    Biochem. Biophys. Res. Commun., 2009-01-09;379(4):964-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
    Authors: Guo B, Chang EY, Cheng G
    J. Clin. Invest., 2008-05-01;118(5):1680-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
    Authors: Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME
    J. Virol., 2005-10-01;79(20):12828-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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