Home / TGF-beta 2 / Recombinant Human TGF-beta 2 Protein

Recombinant Human TGF-beta 2 Protein

Catalog #: 302-B2
86 Citations 5 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
302-B2-002/CF
302-B2-010/CF

With Carrier

Catalog # Availability Size / Price Qty
302-B2-002
302-B2-010
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Recombinant Human TGF-beta 2 Protein Bioactivity
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Product Details
Citations (86)
FAQs
Reviews (5)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human TGF-beta 2 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.025-0.25 ng/mL.
Source
Mouse myeloma cell line, NS0-derived human TGF-beta 2 protein
Ala303-Ser414
Accession #
P61812
N-terminal Sequence
Analysis
Ala303
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.7 kDa (monomer)
SDS-PAGE

12 kDa, reducing conditions
24 kDa, non-reducing conditions

Product Datasheets

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302-B2 (with carrier)

Product Datasheet
COA
SDS

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302-B2/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

302-B2

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 20 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

302-B2/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute 2 µg vial at 5 µg/mL in sterile 4 mM HCl. Reconstitute 10 µg or larger vials at 100 µg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human TGF-beta 2 Protein Bioactivity View Larger

Recombinant Human TGF-beta 2 (Catalog # 302-B2) inhibits Recombinant Mouse IL-4 (Catalog # 404-ML) induced cell proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.025-0.25 ng/mL.

SDS-PAGE Recombinant Human TGF-beta 2 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human TGF-beta 2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 12 kDa and 24 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: TGF-beta 2

TGF-beta 2 (transforming growth factor beta 2) is one of three closely related mammalian members of the large TGF-beta  superfamily that share a characteristic cysteine knot structure (1-7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1-4). Each TGF-beta isoform has some non-redundant functions; for TGF-beta 2, mice with targeted deletion show defects in development of cardiac, lung, craniofacial, limb, eye, ear and urogenital systems (2). Human TGF-beta 2 cDNA encodes a 414 amino acid (aa) precursor that contains a 19 aa signal peptide and a 395 aa proprotein (8). A furin-like convertase processes the proprotein to generate an N-terminal 232 aa latency-associated peptide (LAP) and a C-terminal 112 aa mature TGF-  beta 2 (8, 9). Disulfide-linked homodimers of LAP and TGF-beta 2 remain non-covalently associated after secretion, forming the small latent TGF-beta 1 complex (8-10). Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF-beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature human TGF-beta 2 shows 100% aa identity with porcine, canine, equine and bovine TGF-beta 2, and 97% aa identity with mouse and rat TGF-beta 2. It demonstrates cross-species activity (1). TGF-beta 2 signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta  RIII) and a type II ser/thr kinase receptor termed TGF-beta  RII. This receptor then phosphorylates and activates another ser/thr kinase receptor, TGF-beta  RI (also called activin receptor-like kinase (ALK) -5), or alternatively, ALK-1. The whole complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Use of other signaling pathways that are Smad-independent allows for disparate actions observed in response to TGF-beta in different contexts (11).

References
  1. Sporn, M.B. (2006) Cytokine Growth Factor Rev. 17:3.
  2. Dunker, N. and K. Krieglstein, 2000, Eur. J. Biochem. 267:6982.
  3. Wahl, S.M. (2006) Immunol. Rev. 213:213.
  4. Chang, H. et al. (2002) Endocr. Rev. 23:787.
  5. Lin, J.S. et al. (2006) Reproduction 132:179.
  6. Hinck, A.P. et al. (1996) Biochemistry 35:8517.
  7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
  8. deMartin, R. et al. (1987) EMBO J. 6:3673.
  9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
  10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
  11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
  12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.
Long Name
Transforming Growth Factor beta 2
Entrez Gene IDs
7042 (Human); 21808 (Mouse); 397084 (Porcine)
Alternate Names
BSC-1 cell growth inhibitor; cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; polyergin; TGFB2; TGFbeta 2; TGF-beta 2; TGF-beta2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor, beta 2

Citations for Recombinant Human TGF-beta 2 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

86 Citations: Showing 1 - 10
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  1. Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-? signaling
    Authors: Choi, AS;Jenkins-Lane, LM;Barton, W;Kumari, A;Lancaster, C;Raulerson, C;Ji, H;Altomare, D;Starr, MD;Whitaker, R;Phaeton, R;Arend, R;Shtutman, M;Nixon, AB;Hempel, N;Lee, NY;Mythreye, K;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Identification of ligand-receptor pairs that drive human astrocyte development
    Authors: Voss, AJ;Lanjewar, SN;Sampson, MM;King, A;Hill, EJ;Sing, A;Sojka, C;Bhatia, TN;Spangle, JM;Sloan, SA;
    Nature neuroscience
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  3. A ROCK inhibitor suppresses the transforming growth factor-beta-2-induced endothelial-mesenchymal transition in Schlemm's canal endothelial cells
    Authors: Fujimoto, T;Inoue-Mochita, M;Inoue, T;
    Scientific reports
    Species: Primate - Macaca fascicularis (Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Klotho prevents transforming growth factor-?2-induced senescent-like morphological changes in the retinal pigment epithelium
    Authors: Jang, HY;Kim, SJ;Park, KS;Kim, JH;
    Cell death & disease
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Targeting benign prostate hyperplasia treatments: AR/TGF-beta/NOX4 inhibition by apocynin suppresses inflammation and proliferation
    Authors: BR Jin, HJ Kim, JH Na, WK Lee, HJ An
    Journal of advanced research, 2023-04-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models
    Authors: M Morita, A Yoneda, N Tokunoh, T Masaki, K Shirakura, M Kinoshita, R Hashimoto, N Shigesada, J Takahashi, M Tachibana, S Tanaka, M Obana, N Hino, M Ikawa, K Tsujikawa, C Ono, Y Matsuura, H Kidoya, N Takakura, Y Kubota, T Doi, K Takayama, Y Yoshioka, Y Fujio, Y Okada
    Proceedings of the National Academy of Sciences of the United States of America, 2023-01-12;120(3):e2213317120.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. NFkappaB-Mediated Expression of Phosphoinositide 3-Kinase delta Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells
    Authors: H Han, Y Yang, Z Han, L Wang, L Dong, H Qi, B Liu, J Tian, B Vanhaesebr, A Kazlauskas, G Zhang, S Zhang, H Lei
    Cells, 2023-01-04;12(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. High-throughput 3D microvessel-on-a-chip model to study defective angiogenesis in systemic sclerosis
    Authors: B Kramer, C Corallo, A van den He, J Crawford, T Olivier, E Elstak, N Giordano, P Vulto, HL Lanz, RAJ Janssen, MA Tessari
    Scientific Reports, 2022-10-08;12(1):16930.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. TGF-beta-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells
    Authors: K Santerre, S Cortez Ghi, S Proulx
    Investigative Ophthalmology & Visual Science, 2022-10-03;63(11):3.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor beta2-Induced Trabecular Meshwork Cell Contractility
    Authors: J Knox, G Bou-Ghario, KJ Hamill, CE Willoughby
    Genes, 2022-08-22;13(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-beta2
    Authors: B Callaghan, K Lester, B Lane, X Fan, K Goljanek-W, DA Simpson, C Sheridan, CE Willoughby
    Oncogene, 2022-06-10;12(1):9564.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-beta signaling
    Authors: A Utsunomiya, T Chino, H Kasamatsu, T Hasegawa, N Utsunomiya, VH Luong, T Matsushita, Y Sasaki, D Ogura, SI Niwa, N Oyama, M Hasegawa
    Arthritis Research & Therapy, 2022-04-29;24(1):94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Oxidative Stress Enhances the TGF-beta2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition
    Authors: K Sobierajsk, ME Wawro, J Niewiarows
    International Journal of Molecular Sciences, 2022-02-13;23(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFbeta2 Induced Primary Open Angle Glaucoma
    Authors: RB Kasetti, P Maddineni, B Kodati, B Nagarajan, S Yacoub
    International Journal of Molecular Sciences, 2021-11-19;22(22):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. The effects of exosomes derived from trabecular meshwork cells on Schlemm's canal endothelial cells
    Authors: E Takahashi, J Saruwatari, T Fujimoto, Y Tanoue, T Fukuda, T Inoue
    Scientific Reports, 2021-11-09;11(1):21942.
    Species: Cynomolgus Monkey
    Sample Types: Whole Cells
    Applications: Bioassay
  16. MMP9 Differentially Regulates Proteins Involved in Actin Polymerization and Cell Migration during TGF-beta-Induced EMT in the Lens
    Authors: ZZG Liu, A Taiyab, JA West-Mays
    International Journal of Molecular Sciences, 2021-11-05;22(21):.
    Species: Mouse, Rat
    Sample Types: Whole Tissue
    Applications: Bioassay
  17. Triamcinolone acetonide modulates TGF?beta2?induced angiogenic and tissue?remodeling effects in cultured human retinal pigment epithelial cells
    Authors: CC Hsiao, YC Chang, YT Hsiao, PH Chen, MC Hsieh, WC Wu, YH Kao
    Molecular Medicine Reports, 2021-09-15;24(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
    Authors: T Tabib, M Huang, N Morse, A Papazoglou, R Behera, M Jia, M Bulik, DE Monier, PV Benos, W Chen, R Domsic, R Lafyatis
    Nature Communications, 2021-07-19;12(1):4384.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion
    Authors: WT Shelton, SM Thomas, HR Alexander, CE Thomes, DE Conway, AD Dubash
    Scientific Reports, 2021-06-24;11(1):13295.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Mirna Expression in Glaucomatous and TGFbeta2 Treated Lamina Cribrosa Cells
    Authors: NN Lopez, R Rangan, AF Clark, T Tovar-Vida
    International Journal of Molecular Sciences, 2021-06-08;22(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. ROCK inhibitors beneficially alter the spatial configuration of TGF&beta2-treated 3D organoids from a human trabecular meshwork (HTM)
    Authors: C Ota, Y Ida, H Ohguro, F Hikage
    Sci Rep, 2020-11-20;10(1):20292.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. TGF-&beta-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness
    Authors: T Matsumura, T Fujimoto, A Futakuchi, Y Takihara, F Watanabe-K, E Takahashi, M Inoue-Moch, H Tanihara, T Inoue
    PLoS ONE, 2020-11-18;15(11):e0242626.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. Glucocorticoid-induced cell-derived matrix modulates transforming growth factor &beta2 signaling in human trabecular meshwork cells
    Authors: F Yemanyi, J Vranka, VK Raghunatha
    Scientific Reports, 2020-09-24;10(1):15641.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Disruption of fibronectin fibrillogenesis affects intraocular pressure (IOP) in BALB/cJ mice
    Authors: JA Faralli, MS Filla, CM McDowell, DM Peters
    PLoS ONE, 2020-08-21;15(8):e0237932.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  25. Molecular Genetics and Functional Analysis Implicate CDKN2BAS1-CDKN2B Involvement in POAG Pathogenesis
    Authors: S Rathi, I Danford, HV Gudiseva, L Verkuil, M Pistilli, S Vishwakarm, I Kaur, T Dave, JM O'Brien, VRM Chavali
    Cells, 2020-08-21;9(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  26. Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells
    Authors: SK Meurer, O Tezcan, T Lammers, R Weiskirche
    Cell. Signal., 2020-08-03;74(0):109731.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Osthole Reduces Mouse IOP Associated With Ameliorating Extracellular Matrix Expression of Trabecular Meshwork Cell
    Authors: Y Fan, J Wei, L Guo, S Zhao, C Xu, H Sun, T Guo
    Invest. Ophthalmol. Vis. Sci., 2020-08-03;61(10):38.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  28. Inter-&alpha-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation
    Authors: DC Briggs, AWW Langford-S, HL Birchenoug, TA Jowitt, CM Kielty, JJ Enghild, C Baldock, CM Milner, AJ Day
    J. Biol. Chem., 2020-03-06;0(0):.
    Applications: Surface Plasmon Resonance
  29. DNA methyltransferase inhibitor suppresses fibrogenetic changes in human conjunctival fibroblasts
    Authors: H Yonemura, A Futakuchi, M Inoue-Moch, T Fujimoto, E Takahashi, H Tanihara, T Inoue
    Mol. Vis., 2019-07-21;25(0):382-390.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.
    Authors: Wei X, Zhang L, Zhou Z, Kwon O, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo M, Xu F, Creighton C, Ittmann M, Xin L
    Cell Stem Cell, 2019-04-11;24(5):753-768.e6.
    Species: Mouse
    Sample Types: Transduced Whole Cells
    Applications: Bioassay
  31. PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation
    Authors: M Rutgers, F Bach, L Vonk, M van Rijen, V Akrum, A van Boxtel, W Dhert, L Creemers
    PLoS ONE, 2019-04-04;14(4):e0213483.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Suppression of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells by an MRTF-A Inhibitor
    Authors: M Kobayashi, K Tokuda, Y Kobayashi, C Yamashiro, SH Uchi, M Hatano, K Kimura
    Invest. Ophthalmol. Vis. Sci., 2019-02-01;60(2):528-537.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis
    Authors: H Feng, X Zhao, Q Guo, Y Feng, M Ma, W Guo, X Dong, C Deng, C Li, X Song, S Han, L Cao
    Int. J. Biol. Sci., 2019-01-01;15(3):507-521.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice
    Authors: C Ozek, RC Krolewski, SM Buchanan, LL Rubin
    Sci Rep, 2018-11-23;8(1):17293.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. ?Np63? Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas
    Authors: CG Abraham, MP Ludwig, Z Andrysik, A Pandey, M Joshi, MD Galbraith, KD Sullivan, JM Espinosa
    Cell Rep, 2018-09-18;24(12):3224-3236.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Interleukin-6-mediated trans-signaling inhibits transforming growth factor-? signaling in trabecular meshwork cells
    Authors: M Inoue-Moch, T Inoue, S Kojima, A Futakuchi, T Fujimoto, S Sato-Ohira, U Tsutsumi, H Tanihara
    J. Biol. Chem., 2018-05-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts
    Authors: CC Tsai, SB Wu, HC Kau, YH Wei
    Sci Rep, 2018-05-08;8(1):7276.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions
    Authors: JUG Wagner, E Chavakis, EM Rogg, M Muhly-Rein, SF Glaser, S Günther, D John, F Bonini, AM Zeiher, L Schaefer, MJ Hannocks, RA Boon, S Dimmeler
    Arterioscler. Thromb. Vasc. Biol., 2018-03-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  39. Decreased MCP-1/CCR2 axis-mediated chemotactic effect of conjunctival fibroblasts after transdifferentiation into myofibroblasts
    Authors: U Tsutsumi-K, T Inoue, A Futakuchi, K Shobayashi, E Takahashi, S Kojima, M Inoue-Moch, T Fujimoto, H Tanihara
    Exp. Eye Res., 2018-02-17;170(0):76-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms
    Authors: J Nishida, K Miyazono, S Ehata
    Oncogene, 2018-02-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Autophagy regulates TGF-?2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells
    Authors: J Wu, X Chen, X Liu, S Huang, C He, B Chen, Y Liu
    Mol Med Rep, 2017-12-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Hierarchical patterning modes orchestrate hair follicle morphogenesis
    Authors: JD Glover, KL Wells, F Matthäus, KJ Painter, W Ho, J Riddell, JA Johansson, MJ Ford, CAB Jahoda, V Klika, RL Mort, DJ Headon
    PLoS Biol., 2017-07-11;15(7):e2002117.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  43. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells
    Authors: E Ventura, M Weller, I Burghardt
    J. Immunol., 2017-05-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-? Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation
    Authors: N Selvamurug, Z He, D Rifkin, B Dabovic, NC Partridge
    Stem Cells Int, 2017-04-23;2017(0):2450327.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma
    Authors: N Tellios, JC Belrose, AC Tokarewicz, C Hutnik, H Liu, A Leask, M Motolko, M Iijima, SK Parapuram
    Sci Rep, 2017-04-11;7(1):812.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA)
    Authors: A Futakuchi, T Inoue, T Fujimoto, U Kuroda, M Inoue-Moch, E Takahashi, S Ohira, H Tanihara
    Invest. Ophthalmol. Vis. Sci., 2017-04-01;58(4):2421-2429.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. ERK1/2 signaling is required for the initiation but not progression of TGF?-induced lens epithelial to mesenchymal transition (EMT)
    Authors: MC Wojciechow, L Mahmutovic, DY Shu, FJ Lovicu
    Exp. Eye Res., 2017-03-30;159(0):98-113.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract
    Authors: BA Boswell, A Korol, JA West-Mays, LS Musil
    Mol. Biol. Cell, 2017-02-16;0(0):.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Differential regulation of CD103 (�E integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands
    Authors: MM Roe, S Swain, TA Sebrell, MA Sewell, MM Collins, BA Perrino, PD Smith, LE Smythies, D Bimczok
    J. Leukoc. Biol, 2017-01-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. TGF?2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor
    Sci Rep, 2016-12-07;6(0):38319.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction
    Authors: Michio Nakaya
    J. Clin. Invest, 2016-12-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Cyclosporine A inhibits TGF-?2-induced myofibroblasts of primary cultured human pterygium fibroblasts
    Authors: Sang Il Gum
    Biochem. Biophys. Res. Commun, 2016-12-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling
    Authors: Karthikeyan Mythreye
    J. Biol. Chem., 2016-10-26;291(49):25716-25728.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Transient RUNX1 Expression during Early Mesendodermal Differentiation of�hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling
    Stem Cell Reports, 2016-10-06;7(5):884-896.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516
    PLoS ONE, 2016-09-13;11(9):e0162394.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. K+/Cl- cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2
    J Cell Sci, 2016-08-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
    Authors: Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J
    Nat Med, 2015-04-20;21(5):530-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children.
    Authors: Reeves S, Kolstad T, Lien T, Herrington-Shaner S, Debley J
    Respir Res, 2015-02-13;16(1):21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
    Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
    Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Canonical wnt signaling regulates extracellular matrix expression in the trabecular meshwork.
    Authors: Villarreal G, Chatterjee A, Oh S, Oh D, Kang M, Rhee D
    Invest Ophthalmol Vis Sci, 2014-10-28;55(11):7433-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling.
    Authors: Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J
    PLoS ONE, 2014-05-09;9(5):e96615.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Inhibition by female sex hormones of collagen gel contraction mediated by retinal pigment epithelial cells.
    Authors: Kimura K, Orita T, Fujitsu Y, Liu Y, Wakuta M, Morishige N, Suzuki K, Sonoda K
    Invest Ophthalmol Vis Sci, 2014-04-21;55(4):2621-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens.
    Authors: Gerhart J, Greenbaum M, Scheinfeld V, Fitzgerald P, Crawford M, Bravo-Nuevo A, Pitts M, George-Weinstein M
    PLoS ONE, 2014-04-15;9(4):e95262.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  64. Osteopontin is induced by TGF-beta2 and regulates metabolic cell activity in cultured human optic nerve head astrocytes.
    Authors: Neumann C, Garreis F, Paulsen F, Hammer C, Birke M, Scholz M
    PLoS ONE, 2014-04-09;9(4):e92762.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity.
    Authors: Echeverria C, Montorfano I, Hermosilla T, Armisen R, Velasquez L, Cabello-Verrugio C, Varela D, Simon F
    PLoS ONE, 2014-04-07;9(4):e94146.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Pharmacological regulation of SPARC by lovastatin in human trabecular meshwork cells.
    Authors: Villarreal G, Chatterjee A, Oh S, Oh D, Rhee D
    Invest Ophthalmol Vis Sci, 2014-03-19;55(3):1657-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury.
    Authors: Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, Sieber-Blum M
    Stem Cells Transl Med, 2014-01-17;3(3):334-45.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  68. MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses.
    Authors: Volkmann I, Kumarswamy R, Pfaff N, Fiedler J, Dangwal S, Holzmann A, Batkai S, Geffers R, Lother A, Hein L, Thum T
    Circ Res, 2013-08-19;113(8):997-1003.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. miR-21 represses Pdcd4 during cardiac valvulogenesis.
    Authors: Kolpa, Heather, Peal, David S, Lynch, Stacey N, Giokas, Andrea C, Ghatak, Shibnath, Misra, Suniti, Norris, Russell, Macrae, Calum A, Markwald, Roger R, Ellinor, Patrick, Bischoff, Joyce, Milan, David J
    Development, 2013-04-11;140(10):2172-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. TGFbeta signalling plays an important role in IL4-induced alternative activation of microglia.
    J Neuroinflammation, 2012-09-04;9(0):210.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.
    Authors: Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, Dana R, Masli S
    J. Exp. Med., 2011-05-02;208(5):1083-92.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
    Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
    Mol. Biol. Cell, 2011-03-16;22(10):1686-98.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  74. TGFbeta2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.
    Authors: Craig EA, Craig E, Austin AF, Austin A, Vaillancourt RR, Vaillancourt R, Barnett JV, Camenisch TD, Camenisch T
    Exp Cell Res, 2010-07-13;316(20):3397-405.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.
    Authors: Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y
    J. Biol. Chem., 2009-12-03;285(0):4975-82.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  76. Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor.
    Authors: Kuchtey J, Kallberg ME, Gelatt KN, Rinkoski T, Komaromy AM, Kuchtey RW
    Invest. Ophthalmol. Vis. Sci., 2008-04-17;49(8):3438-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
    Authors: Barkho BZ, Song H, Aimone JB
    Stem Cells Dev., 2006-06-01;15(3):407-21.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
    Authors: Neurohr C, Nishimura SL, Sheppard D
    Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling.
    Authors: Close JL, Gumuscu B, Reh TA
    Development, 2005-07-01;132(13):3015-26.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
    Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2005-04-01;203(1):35-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice.
    Authors: Saika S, Kono-Saika S, Tanaka T, Yamanaka O, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Yoo J, Flanders KC, Roberts AB
    Lab. Invest., 2004-10-01;84(10):1245-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells.
    Authors: Murphy SJ, Dore JJ, Edens M, Coffey RJ, Barnard JA, Mitchell H, Wilkes M, Leof EB
    Mol. Biol. Cell, 2004-04-09;15(6):2853-62.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22.
    Applications: ELISA (Standard)
  84. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
    Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
    Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56.
    Applications: ELISA (Standard)
  85. TGF-beta 2 attenuates the injury-induced death of mature motoneurons.
    Authors: Jiang Y, Zhang M, Koishi K, McLennan IS
    J. Neurosci. Res., 2000-12-15;62(6):809-13.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  86. Isoform specificity of commercially-available anti-TGF-beta antibodies.
    Authors: Mozes MM, Hodics T, Kopp JB
    J. Immunol. Methods, 1999-05-27;225(1):87-93.
    Applications: Western Blot

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Recombinant Human TGF-beta 2 Protein
By Anonymous on 05/15/2024
Application: Immunoassay Standard
Reason for Rating: Compatible with Quantikine assay. Used for spike-and-recovery assessment in plasma.
Recombinant Human TGF-beta 2 Protein
By Anonymous on 10/26/2021

Reason for Rating: Successful downregulation of target protein
Recombinant Human TGF-beta 2 Protein
By Jenna Nguyen on 05/07/2019
Application: Media additive for protein or antibody production
Recombinant Human TGF-beta 2 Protein
By Anonymous on 04/10/2018
Application: In vitro bioactivity in cell culture
Reason for Rating: This protein make cells well-responded. Induced the target protein in the cells.
In vitro bioactivity in cell culture Recombinant Human TGF-beta 2 Protein 302-B2
Recombinant Human TGF-beta 2 Protein
By Feryan Ahmed on 05/17/2016
Application: In vitro bioactivity in cell culture