Recombinant Human IGF-I/IGF-1 Protein, CF

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves' Orbitopathy
Authors: Byeon, HJ;Chae, MK;Ko, J;Lee, EJ;Kikkawa, DO;Jang, SY;Yoon, JS;
Investigative ophthalmology & visual science
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of follicle-stimulating hormone, insulin-like growth factor 1, fibroblast growth factor 2, and fibroblast growth factor 9 on sirtuins expression and histone deacetylase activity in bovine granulosa cells
Authors: Archilia, EC;Bello, CAP;Batalha, IM;Wulstein, K;Enriquez, C;Schütz, LF;
Theriogenology
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells
Authors: Meng, F;Zhang, S;Xie, J;Zhou, Y;Wu, Q;Lu, B;Zhou, S;Zhao, X;Li, Y;
Journal of hematology & oncology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like growth factor1 preserves gastric pacemaker cells and motor function in aging via ERK1/2 activation
Authors: Nguyen, VTT;Taheri, N;Choi, EL;Kellogg, TA;Linden, DR;Hayashi, Y;
Cellular and molecular gastroenterology and hepatology
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Bioassay

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling
Authors: Rashid, MI;Ito, T;Miya, F;Shimojo, D;Arimoto, K;Onodera, K;Okada, R;Nagashima, T;Yamamoto, K;Khatun, Z;Shimul, RI;Niwa, JI;Katsuno, M;Sobue, G;Okano, H;Sakurai, H;Shimizu, K;Doyu, M;Okada, Y;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells
Authors: Maylem, ERS;Spicer, LJ;Batalha, IM;Sch�tz, LF;
Domestic animal endocrinology
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage
Authors: CA Hayes, NI Morgan, KC Thomas, MJ Pushie, A Vijayasank, BG Ashmore, K Wontor, MA De Leon, NM Ashpole
bioRxiv : the preprint server for biology, 2023-04-02;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G>A (p.D249N) autosomal dominant mutation in TUBB4A
Authors: AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver
Stem Cell Research, 2023-03-26;69(0):103083.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pervasive environmental chemicals impair oligodendrocyte development
Authors: EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar
bioRxiv : the preprint server for biology, 2023-02-12;0(0):.
Species: Human, Mouse
Sample Types: Organoid, Whole Cells
Applications: Bioassay

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective
Authors: HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman
bioRxiv : the preprint server for biology, 2023-02-10;0(0):.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome
Authors: NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich
International Journal of Molecular Sciences, 2023-02-09;24(4):.
Species: Human
Sample Types: Spheroid
Applications: Bioassay

Binucleated human bone marrow-derived mesenchymal cells can be formed during neural-like differentiation with independence of any cell fusion events
Authors: C Bueno, M Blanquer, D García-Ber, S Martínez, JM Moraleda
Scientific Reports, 2022-11-30;12(1):20615.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture
Authors: PY Su, W Lee, J Zernant, SH Tsang, T Nagasaki, B Corneo, R Allikmets
Oncogene, 2022-11-14;65(0):102973.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like growth factor 1 and the hormonal mediation of sibling rivalry
Authors: M Ridenour, LJ Spicer, JL Grindstaff
General and comparative endocrinology, 2022-11-07;330(0):114163.
Species: Eastern Bluebirds
Sample Types: Plasma
Applications: Bioassay

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration
Authors: ESY Ng, N Kady, J Hu, A Dave, Z Jiang, J Pei, MB Gorin, A Matynia, RA Radu
Cells, 2022-11-02;11(21):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation
Authors: F Fang, L Xu, L Liang, M Qu, H Yao, W Yue, L Chen, D Chen, Z Fan, L He, X Nan, H Zhang, X Xie, X Pei
Cell Death & Disease, 2022-10-21;13(10):886.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro
Authors: T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle
Nature Communications, 2022-09-15;13(1):5427.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway
Authors: Z Liu, D Meng, J Wang, H Cao, P Feng, S Wu, N Wang, C Dang, P Hou, P Xia
Cell Death & Disease, 2022-08-30;13(8):751.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
Authors: Y Tang, DJ Kwiatkowsk, EP Henske
Nature Communications, 2022-08-26;13(1):5018.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay
Authors: S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller
Nature Communications, 2022-08-25;13(1):5003.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hormone regulation of thrombospondin-1 mRNA in porcine granulosa cells in vitro
Authors: LJ Spicer, JR Evans, NB Schreiber
Oncogene, 2022-07-26;244(0):107048.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder
Authors: IB Kim, T Lee, J Lee, J Kim, S Lee, IG Koh, JH Kim, JY An, H Lee, WK Kim, YS Ju, Y Cho, SJ Yu, SA Kim, M Oh, DW Han, E Kim, JK Choi, HJ Yoo, JH Lee
Oncogene, 2022-07-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Authors: C Nunes, L Depestel, L Mus, KM Keller, L Delhaye, A Louwagie, M Rishfi, A Whale, N Kara, SR Andrews, F Dela Cruz, D You, A Siddiquee, CT Cologna, S De Craemer, E Dolman, C Bartenhage, F De Vloed, E Sanders, A Eggermont, SL Bekaert, W Van Loocke, JW Bek, G Dewyn, S Loontiens, G Van Isterd, B Decaesteke, L Tilleman, F Van Nieuwe, V Vermeirsse, C Van Neste, B Ghesquiere, S Goossens, S Eyckerman, K De Preter, M Fischer, J Houseley, J Molenaar, B De Wilde, SS Roberts, K Durinck, F Speleman
Science Advances, 2022-07-13;8(28):eabn1382.
Species: Human
Sample Types: Organoids
Applications: Bioassay

Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis
Authors: V Kheirollah, A Khadim, G Kiliaris, M Korfei, MM Barroso, I Alexopoulo, AI Vazquez-Ar, M Wygrecka, C Ruppert, A Guenther, W Seeger, S Herold, E El Agha
Cells, 2022-06-20;11(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor
Authors: MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn
Biomolecules, 2022-06-18;12(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells
Authors: M Berlak, E Tucker, M Dorel, A Winkler, A McGearey, E Rodriguez-, BM da Costa, K Barker, E Fyle, E Calton, S Eising, K Ober, D Hughes, E Koutrouman, P Carter, R Stankunait, P Proszek, N Jain, C Rosswog, H Dorado-Gar, JJ Molenaar, M Hubank, G Barone, J Anderson, P Lang, HE Deubzer, A Künkele, M Fischer, A Eggert, C Kloft, AG Henssen, M Boettcher, F Hertwig, N Blüthgen, L Chesler, JH Schulte
Molecular Cancer, 2022-06-10;21(1):126.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of hiPSC-Derived Skeletal Muscle Cells: Exploiting the Potential of Skeletal Muscle-Derived hiPSCs
Authors: E Metzler, H Escobar, DY Sunaga-Fra, S Sauer, S Diecke, S Spuler
Biomedicines, 2022-05-23;10(5):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids
Authors: KMA De Kleijn, KR Straasheij, WA Zuure, GJM Martens
Biomedicines, 2022-04-29;10(5):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells
Authors: SA Luff, JP Creamer, S Valsoni, C Dege, R Scarfò, A Dacunto, S Cascione, LN Randolph, E Cavalca, I Merelli, SA Morris, A Ditadi, CM Sturgeon
Nature Cell Biology, 2022-04-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Physical and functional interactome atlas of human receptor tyrosine kinases.
Authors: Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M
EMBO Rep, 2022-04-05;23(6):e54041.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia
Authors: SL Pereira, ME Shoemaker, S Gawel, GJ Davis, M Luo, VA Mustad, JT Cramer
Nutrients, 2022-03-11;14(6):.
Species: Human
Sample Types: Plasma
Applications: Bioassay

Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells
Authors: MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto
Oncogene, 2022-02-21;31(0):100852.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
Authors: L Zhu, D Retana, P García-Góm, L Álvaro-Esp, N Priego, M Masmudi-Ma, N Yebra, L Miarka, E Hernández-, C Blanco-Apa, S Martínez, C Sobrino, N Ajenjo, MJ Artiga, E Ortega-Pai, R Torres-Rui, S Rodríguez-, RENACER, R Soffietti, L Bertero, P Cassoni, T Weiss, J Muñoz, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, O Toldos, Y Ruano, L Alcázar, G Blasco, J Fernández-, E Caleiras, M Lafarga, D Megías, O Graña-Cast, C Nör, MD Taylor, LS Young, D Varešlija, N Cosgrove, FJ Couch, L Cussó, M Desco, S Mouron, M Quintela-F, M Weller, J Pastor, M Valiente
Embo Molecular Medicine, 2022-02-17;0(0):e14552.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells
Authors: KN Lin, K Zhang, W Zhao, SY Huang, H Li
International Journal of Molecular Sciences, 2022-01-28;23(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus
Authors: FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford
Cell Transplantation, 2022-01-01;31(0):9636897221101.
Species: Human
Sample Types: Embryoid Bodies
Applications: Bioassay

Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL
Authors: G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker
Stem Cell Research, 2021-12-23;59(0):102635.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients
Authors: AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles
Cells, 2021-11-10;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds
Authors: KD Abu-Bonsra, DF Newgreen, M Dottori
Cells, 2021-10-26;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis
Authors: PR Gajjala, RK Kasam, D Soundarara, D Sinner, SK Huang, AG Jegga, SK Madala
JCI Insight, 2021-10-22;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Use of Human Serum Samples to Study Malignant Transformation: A Pilot Study
Authors: AN Holowatyj, B Gigic, CA Warby, J Ose, T Lin, P Schrotz-Ki, CM Ulrich, JJ Bernard
Cells, 2021-10-06;10(10):.
Species: Human
Sample Types: Serum
Applications: Bioassay

Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia
Authors: AM Thiebaut, I Buendia, V Ginet, E Lemarchand, MB Boudjadja, Y Hommet, L Lebouvier, C Lechevalli, M Maillasson, E Hedou, N Déglon, F Oury, M Rubio, J Montaner, J Puyal, D Vivien, BD Roussel
Autophagy, 2021-09-14;0(0):1-21.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay

Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies
Authors: W M Kholosy, M Derieppe, F van den Ha, K Ober, Y Su, L Custers, L Schild, L M J van Zo, L M Wellens, H R Ariese, CL Szanto, J Wienke, MP Dierselhui, D van Vuurde, EM Dolman, JJ Molenaar
Journal of personalized medicine, 2021-08-30;11(9):.
Species: Human
Sample Types: Organoids
Applications: Bioassay

PI3K/AKT phosphorylation activates ERRalpha by upregulating PGC?1alpha and PGC?1beta in gallbladder cancer
Authors: L Wang, M Yang, H Jin
Molecular Medicine Reports, 2021-06-29;24(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity
Authors: G Iannello, A Patel, D Sirabella, B Corneo, V Thaker
Stem Cell Research, 2021-06-21;54(0):102432.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands
Authors: KMA Abdel-Raou, R Rezgui, C Stefanini, JCM Teo, N Christofor
Biology, 2021-06-16;10(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R
Authors: C Qiao, W Huang, J Chen, W Feng, T Zhang, Y Wang, D Liu, X Ji, M Xie, M Sun, D Fan, K Wu, L Xia
Cell Death & Disease, 2021-06-01;12(6):564.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients
Authors: J Borsoi, M Morato-Mar, F de Araújo, L Assis Pere, LE Farinha-Ar, R Delgado Sa, AB Alvarez Pe, L Veiga Pere
Stem Cell Research, 2021-05-25;54(0):102407.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
Authors: C de O Mende, C Lopes-Siqu, F Pettito-As, M Pereira-Ol, MP de Oliveir, C Pirmez, AM Da-Cruz, H Goto
Journal of Immunology Research, 2021-03-29;2021(0):6657785.
Species: L. braziliensis
Sample Types: Whole Cells
Applications: Bioassay

Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in�vitro
Authors: M Chiara Per, N Bellitto, ERS Maylem, F Caloni, LJ Spicer
Theriogenology, 2021-03-28;168(0):1-12.
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
Authors: X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong
Cell Reports, 2021-03-02;34(9):108802.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor
Authors: J Sheff, P Wang, P Xu, M Arbour, L Masson, H van Faasse, G Hussack, K Kemmerich, E Brunette, D Stanimirov, JJ Hill, J Kelly, F Ni
Scientific Reports, 2021-02-19;11(1):4284.
Species: Human
Sample Types: Whole Cells
Applications: Surface Plasmon Resonance

Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
Authors: E Solomon, K Davis-Ande, B Hovde, S Micheva-Vi, JF Harris, S Twary, R Iyer
BMC molecular and cell biology, 2021-02-18;22(1):13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells
Authors: M Mohrin, J Liu, J Zavala-Sol, S Bhargava, J Maxwell Tr, A Brito, D Hu, D Brooks, G Koukos, L Alabdulaal, JS Paw, K Hake, G Kolumam, ML Bouxsein, R Baron, Y Kutskova, A Freund
Aging Cell, 2021-02-09;0(0):e13313.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chondrogenesis of human amniotic fluid stem cells in Chitosan-Xanthan scaffold for cartilage tissue engineering
Authors: CC Zuliani, II Damas, KC Andrade, CB Westin, ÂM Moraes, IB Coimbra
Scientific Reports, 2021-02-04;11(1):3063.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress
Authors: C Phoomak, W Cui, TJ Hayman, SH Yu, P Zhao, L Wells, R Steet, JN Contessa
Science Advances, 2021-01-15;7(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
Authors: C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi
Cell Stem Cell, 2021-01-04;28(2):331-342.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Establishment of a New Device for Electrical Stimulation of Non-Degenerative Cartilage Cells In Vitro
Authors: S Krueger, A Riess, A Jonitz-Hei, A Weizel, A Seyfarth, H Seitz, R Bader
International Journal of Molecular Sciences, 2021-01-01;22(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study
Authors: A Andueza, S Kumar, J Kim, DW Kang, HL Mumme, JI Perez, N Villa-Roel, H Jo
Cell Reports, 2020-12-15;33(11):108491.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons
Authors: ST Chen, WJ Lai, WJ Zhang, QP Chen, LB Zhou, KF So, LL Shi
Neural Regen Res, 2020-12-01;15(12):2335-2343.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
Authors: L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin
Nat Commun, 2020-11-17;11(1):5842.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
Cell Stem Cell, 2020-10-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress
Authors: NV Hewawasam, F Lhaf, HA Taylor, K Viloria, A Austin, A King, P Jones, L Jones, MD Turner, NJ Hill
Sci Rep, 2020-09-25;10(1):15741.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IGF-1R stimulation alters microglial polarization via TLR4/NF-kappaB pathway after cerebral hemorrhage in mice
Authors: Z Sun, K Wu, L Gu, L Huang, Q Zhuge, S Yang, Z Wang
Brain Res. Bull., 2020-08-29;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis
Authors: DP Ha, AS Lee
Cell. Signal., 2020-08-14;75(0):109736.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells
Authors: S Riccetti, A Sinigaglia, G Desole, N Nowotny, M Trevisan, L Barzon
Viruses, 2020-08-12;12(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Protein tyrosine phosphatase 1B as a therapeutic target for Graves' orbitopathy in an in vitro model
Authors: HJ Byeon, JY Kim, J Ko, EJ Lee, K Don, JS Yoon
PLoS ONE, 2020-08-06;15(8):e0237015.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture

Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing
Authors: Y Nanki, T Chiyoda, A Hirasawa, A Ookubo, M Itoh, M Ueno, T Akahane, K Kameyama, W Yamagami, F Kataoka, D Aoki
Sci Rep, 2020-07-28;10(1):12581.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Controlled Delivery of Insulin-like Growth Factor-1 from Bioactive Glass-Incorporated Alginate-Poloxamer/Silk Fibroin Hydrogels
Authors: Q Min, X Yu, J Liu, Y Zhang, Y Wan, J Wu
Pharmaceutics, 2020-06-20;12(6):.
Species: N/A
Sample Types: Nanoparticles
Applications: Bioassay

Mapping developmental trajectories and subtype diversity of normal and glaucomatous human retinal ganglion cells by single-cell transcriptome analysis
Authors: P Teotia, M Niu, I Ahmad
Stem Cells, 2020-06-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
Authors: L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna
Aging (Albany NY), 2020-04-17;12(8):6823-6851.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Different regulation of lipogenesis in sebocytes and subcutaneous preadipocytes in hamsters in vitro
Authors: T Sato, F Shibata, T Koiwai, N Akimoto
Biochem Biophys Rep, 2020-04-10;22(0):100761.
Species: Hamster
Sample Types: Whole Cells
Applications: Cell Culture

Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs
Authors: K Onodera, D Shimojo, Y Ishihara, M Yano, F Miya, H Banno, N Kuzumaki, T Ito, R Okada, B de Araújo, M Ohyama, M Yoshida, T Tsunoda, M Katsuno, M Doyu, G Sobue, H Okano, Y Okada
Mol Brain, 2020-02-19;13(1):18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies
Authors: K Kawai, R Negoro, M Ichikawa, T Yamashita, S Deguchi, K Harada, K Hirata, K Takayama, H Mizuguchi
Mol Ther Methods Clin Dev, 2019-11-21;17(0):49-57.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors
Authors: M Matjusaiti, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, A Williams, SM Pollard
Stem Cell Reports, 2019-11-07;13(6):1053-1067.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields
Authors: S Krueger, S Achilles, J Zimmermann, T Tischer, R Bader, A Jonitz-Hei
J Clin Med, 2019-10-24;8(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination
Authors: A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta
Cell Rep, 2019-10-22;29(4):904-919.e9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V2a interneuron differentiation from mouse and human pluripotent stem cells
Authors: JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt
Nat Protoc, 2019-10-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells
Authors: Z Wang, G Liu, J Mao, M Xie, M Zhao, X Guo, S Liang, H Li, X Li, R Wang
Mediators Inflamm., 2019-07-31;2019(0):5497467.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of N-carbamylglutamate and arginine on steroidogenesis and proliferation of pig granulosa cells in vitro
Authors: T Feng, AA DeVore, MC Perego, BC Morrell, LJ Spicer
Anim. Reprod. Sci., 2019-07-26;209(0):106138.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
Authors: Z Liu, M Osipovitch, A Benraiss, NPT Huynh, R Foti, J Bates, D Chandler-M, RL Findling, PJ Tesar, M Nedergaard, MS Windrem, SA Goldman
Cell Rep, 2019-06-25;27(13):3832-3843.e6.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells
Authors: K Endo, N Fujita, T Nakagawa, R Nishimura
J. Vet. Med. Sci., 2019-06-04;0(0):.
Species: Human
Sample Types: Whole Cell
Applications: Bioassay

Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector
Authors: S Mayers, PD Moço, T Maqbool, PN Silva, DM Kilkenny, J Audet
BMC Biotechnol., 2019-04-15;19(1):21.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
Cell Rep, 2019-04-09;27(2):599-615.e12.
Species: Human
Sample Types: cell culture
Applications: Differentiation, Differentiation

A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma
Authors: YB Pang, J He, BY Cui, S Xu, XL Li, MY Wu, R Liang, Y Feng, X Guo, XH Zhang, XL Luo
Stem Cells Int, 2019-04-01;2019(0):5680327.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide?3 kinase/protein kinase B signaling pathway
Authors: D Zhang, A Wang, J Feng, Q Zhang, L Liu, H Ren
Mol Med Rep, 2019-03-27;19(5):4019-4026.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
JCI Insight, 2019-03-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes
Authors: CA Conover, LK Bale, RL Frye, HV Schaff
Physiol Rep, 2019-02-01;7(4):e14006.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Selective estrogen receptor modulators enhance CNS remyelination independent of estrogen receptors
Authors: KA Rankin, F Mei, K Kim, YA Shen, SR Mayoral, C Desponts, DS Lorrain, AJ Green, SE Baranzini, JR Chan, R Bove
J. Neurosci., 2019-01-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
Authors: G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, Z Hou, Z Cai, G Jin, CC Hsu, YH Wang, J Hu, TY Chen, H Li, MG Lee, HK Lin
Nat. Cell Biol., 2019-01-28;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9
Authors: LP Foltz, SE Howden, JA Thomson, DO Clegg
Int J Mol Sci, 2018-12-19;19(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation
Authors: M Osipovitch, A Asenjo Mar, JN Mariani, A Cornwell, S Dhaliwal, L Zou, D Chandler-M, S Wang, X Li, SJ Benraiss, R Agate, A Lampp, A Benraiss, MS Windrem, SA Goldman
Cell Stem Cell, 2018-12-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in�vitro
Authors: J Li, J Zheng
Mol Med Rep, 2018-12-12;19(2):821-830.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies
Authors: R Negoro, K Takayama, K Kawai, K Harada, F Sakurai, K Hirata, H Mizuguchi
Stem Cell Reports, 2018-11-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
Authors: B Decaesteke, G Denecker, C Van Neste, EM Dolman, W Van Loocke, M Gartlgrube, C Nunes, F De Vloed, P Depuydt, K Verboom, D Rombaut, S Loontiens, J De Wyn, WM Kholosy, B Koopmans, AHW Essing, C Herrmann, D Dreidax, K Durinck, D Deforce, F van Nieuwe, A Henssen, R Versteeg, V Boeva, G Schleierma, J van Nes, P Mestdagh, S Vanhauwaer, JH Schulte, F Westermann, JJ Molenaar, K De Preter, F Speleman
Nat Commun, 2018-11-19;9(1):4866.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
Authors: TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal
Mol. Cancer Ther., 2018-11-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
Authors: H Takeuchi, S Inagaki, W Morozumi, Y Nakano, Y Inoue, Y Kuse, T Mizoguchi, S Nakamura, M Funato, H Kaneko, H Hara, M Shimazawa
Sci Rep, 2018-11-06;8(1):16443.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
Authors: IF LaRocque-d, JDB Rocha, MP Nunes, PAV Oliveira, DO Nascimento, L Freire-de-, CM Takiya, A Morrot, D Decote-Ric, JO Previato, GA DosReis, L Mendonça-P, CG Freire-de-
Sci Rep, 2018-11-06;8(1):16378.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation and characterization of two human induced pluripotent stem cell (hiPSC) lines homozygous for the Apolipoprotein e4 (APOE4) risk variant-Alzheimer's disease (ASUi005-A) and healthy non-demented control (ASUi006-A)
Authors: N Brookhouse, P Zhang, R Caselli, JJ Kim, DA Brafman
Stem Cell Res, 2018-09-21;32(0):145-149.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Development of a Graphene Oxide-Incorporated Polydimethylsiloxane Membrane with Hexagonal Micropillars
Authors: YY Lin, Y Chien, JH Chuang, CC Chang, YP Yang, YH Lai, WL Lo, KH Chien, TI Huo, CY Wang
Int J Mol Sci, 2018-08-25;19(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection
Authors: LC Reis, EM Ramos-Sanc, F Petitto-As, AH Nerland, M Hernandez-, F Selheim, LM Floeter-Wi, H Goto
Mediators Inflamm., 2018-07-29;2018(0):9787128.
Species: Mouse
Sample Types: In Vivo

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
Authors: S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez
Nat Commun, 2018-07-23;9(1):2886.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain
Authors: FC Yang, J Draper, PG Smith, JL Vivian, SM Shapiro, JA Stanford
Cell Transplant, 2018-05-30;0(0):9636897187663.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of Human Induced Pluripotent Stem Cells Using a Defined, Feeder-Free Reprogramming System.
Authors: Park S, Mostoslavsky G
Curr Protoc Stem Cell Biol, 2018-05-04;45(1):e48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma
Authors: MK Shanmugam, KS Ahn, JH Lee, R Kannaiyan, N Mustafa, KA Manu, KS Siveen, G Sethi, WJ Chng, AP Kumar
Front Pharmacol, 2018-05-03;9(0):365.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
Authors: CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs
Genes Dev., 2018-03-19;32(5):373-388.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulation of hyaluronan polymer size regulates proliferation of perimysial fibroblasts in thyroid eye disease
Authors: R Ma, Q Li, Z Wang, Y Yuan, L Gan, J Qian
Biochem. Biophys. Res. Commun., 2018-02-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chromosomal instability during neurogenesis in Huntington's disease
Authors: A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, H Wang, M Fenner, S Tse, A Marks, C Nchako, AH Brivanlou
Development, 2018-01-29;145(2):.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia
Authors: V Sobrino, P González-R, V Annese, J López-Barn, R Pardal
EMBO Rep., 2018-01-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction
Authors: G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao
EBioMedicine, 2018-01-13;28(0):287-302.
Species: Human
Sample Types: Complex Sample Type
Applications: Bioassay

Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
Authors: Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P Henske, Fabrice Roegiers, Krinio Giannikou, David J Kwiatkows, Hossein Mansouri, Maciej M Markiewsk, Brandon White, Magdalena Karbownic
Nature Communications, 2017-11-29;0(0):2041-1723.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of M�ller Glia-Derived Progenitor Cells in the Avian Retina
Authors: L Todd, L Suarez, C Quinn, AJ Fischer
Stem Cells, 2017-11-27;0(0):.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures
Authors: P Haynes, K Kernan, SL Zhou, DG Miller
Skelet Muscle, 2017-06-21;7(1):13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
Authors: Hugh S O'Neill
J Tissue Eng Regen Med, 2017-06-19;0(0):.
Species: N/A
Sample Types: Complex Sample Type
Applications: Bioassay

Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate
Authors: JR Chao, DA Lamba, TR Klesert, A Torre, A Hoshino, RJ Taylor, A Jayabalu, AL Engel, TH Khuu, RK Wang, M Neitz, J Neitz, TA Reh
Transl Vis Sci Technol, 2017-05-16;6(3):4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway
Authors: TT Li, D Zhu, T Mou, Z Guo, JL Pu, QS Chen, XF Wei, ZJ Wu
Mol. Immunol., 2017-04-25;87(0):132-140.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells
Authors: DJ Tischfield, J Kim, SA Anderson
Stem Cell Reports, 2017-04-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
Am. J. Hum. Genet., 2017-03-30;100(4):617-634.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential involvement of the microtubule cytoskeleton in Insulin Receptor Substrate-1 (IRS-1) and IRS-2 signaling to AKT determines response to microtubule disruption in breast carcinoma cells
Authors: J Mercado-Ma, JL Clark, AJ Piper, J Janusis, LM Shaw
J. Biol. Chem, 2017-03-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
Stem Cell Res, 2017-03-18;21(0):19-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration
Authors: Z Geng, PJ Walsh, V Truong, C Hill, M Ebeling, RJ Kapphahn, SR Montezuma, C Yuan, H Roehrich, DA Ferrington, JR Dutton
PLoS ONE, 2017-03-10;12(3):e0173575.
Species: Human
Sample Types: Transduced Whole Cells
Applications: Bioassay

Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
Sci Rep, 2017-03-02;7(0):43736.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion
Authors: T Garrido-Go, K Ona, M Kapidzic, M Gormley, C Simón, O Genbacev, SJ Fisher
Development, 2017-03-01;144(5):767-777.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Experimental Study of the Biological Properties of Human Embryonic Stem Cell-Derived Retinal Progenitor Cells
Authors: J Shao, PY Zhou, GH Peng
Sci Rep, 2017-02-13;7(0):42363.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin-Like Growth Factor-1 Increases the Expression of Inflammatory Biomarkers and Sebum Production in Cultured Sebocytes
Authors: H Kim, SY Moon, MY Sohn, WJ Lee
Ann Dermatol, 2017-02-03;29(1):20-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders
Authors: C Lorenz, P Lesimple, R Bukowiecki, A Zink, G Inak, B Mlody, M Singh, M Semtner, N Mah, K Aur‚, M Leong, O Zabiegalov, EM Lyras, V Pfiffer, B Fauler, J Eichhorst, B Wiesner, N Huebner, J Priller, T Mielke, D Meierhofer, Z Izsv k, JC Meier, F Bouillaud, J Adjaye, M Schuelke, EE Wanker, A LombŠs, A Prigione
Cell Stem Cell, 2017-01-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IGF-IR cooperates with ER? to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules
Authors: NA Afratis, P Bouris, SS Skandalis, HA Multhaupt, JR Couchman, AD Theocharis, NK Karamanos
Sci Rep, 2017-01-12;7(0):40138.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
Authors: G Dalton, SW An, SI Al-Juboori, N Nischan, J Yoon, E Dobrinskik, DW Hilgemann, J Xie, K Luby-Phelp, JJ Kohler, L Birnbaumer, CL Huang
Proc. Natl. Acad. Sci. U.S.A, 2017-01-09;114(4):752-757.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
Authors: Ivan Carcamo-Or
Cell Stem Cell, 2016-12-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
Authors: L J Spicer
Domest. Anim. Endocrinol, 2016-12-11;59(0):90-99.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Evidence for direct effects of glyphosate on ovarian function: glyphosate influences steroidogenesis and proliferation of bovine granulosa but not theca cells in vitro
Authors: Maria Chiara Perego
J Appl Toxicol, 2016-12-05;0(0):.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

TGF? signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells
Authors: Tong Wu
Mol. Carcinog., 2016-11-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle
Authors: L J Spicer
Mol. Cell. Endocrinol., 2016-11-03;0(0):.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
Nat Commun, 2016-09-26;7(0):12961.
Species: Human
Sample Types:
Applications: Neutralization

Polyurethane scaffolds seeded with CD34(+) cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors
Sci Rep, 2016-08-30;6(0):32149.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds
Sci Rep, 2016-07-06;6(0):29408.
Species: Human
Sample Types:

IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
Authors: Matthew N Svalina
Sci Rep, 2016-06-03;6(0):27012.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Structural and functional investigations of the effector protein LpiR1 from Legionella pneumophila
J Biol Chem, 2016-05-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma
Genome Biol, 2016-04-29;17(1):80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients
Authors: L Bieghs, M Brohus, IB Kristensen, N Abildgaard, M Bøgsted, HE Johnsen, CA Conover, E De Bruyne, K Vanderkerk, MT Overgaard, M Nyegaard
PLoS ONE, 2016-04-25;11(4):e0154256.
Species: Human
Sample Types: Plasma
Applications: Bioassay

Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age
Authors: Peter E Clayton
Pediatr. Res., 2016-04-08;80(2):299-305.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
Authors: Yasuhiro Ikeda
Stem Cells Transl Med, 2016-03-17;5(5):694-702.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
Authors: Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G
Nat Commun, 2015-03-26;6(0):6576.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
PLoS ONE, 2015-03-25;10(3):e0122149.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
Authors: Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H
J Clin Invest, 2015-02-09;125(3):1243-54.
Species: Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma.
Authors: Bolomsky A, Hose D, Schreder M, Seckinger A, Lipp S, Klein B, Heintel D, Ludwig H, Zojer N
J Hematol Oncol, 2015-02-08;8(1):10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.
Authors: Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H
J Biol Chem, 2015-01-07;290(9):5438-48.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.
Authors: Lee H, Lee J, Lee S, Cho H, Song H, Jeong D, Seo Y, Shin S, Joung J, Kwon Y, Choi Y, Park W, Lee H, Seol H, Shim Y, Joo K, Nam D
Clin Cancer Res, 2014-12-30;21(5):1172-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
Authors: Crosley, Erin J, Dunk, Caroline, Beristain, Alexande, Christians, Julian K
Reprod Biol Endocrinol, 2014-12-04;12(0):123.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
J Biol Chem, 2014-11-12;290(1):467-77.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3beta and ZEB2 in the BGC-823 gastric cancer cell line.
Authors: Li H, Xu L, Zhao L, Ma Y, Zhu Z, Liu Y, Qu X
Oncol Lett, 2014-11-07;9(1):143-148.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
Authors: Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M
Stem Cells, 2014-10-01;32(10):2714-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.
Authors: Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M
Cancer Res, 2014-09-30;74(24):7418-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi.
Authors: Drexler A, Pietri J, Pakpour N, Hauck E, Wang B, Glennon E, Georgis M, Riehle M, Luckhart S
PLoS Pathog, 2014-06-26;10(6):e1004231.
Species: Insect
Sample Types: In Vivo
Applications: In Vivo

Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
Cancer Res, 2014-06-16;74(16):4458-69.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells.
Authors: Li H, Xu L, Li C, Zhao L, Ma Y, Zheng H, Li Z, Zhang Y, Wang R, Liu Y, Qu X
Mol Cancer, 2014-06-02;13(0):136.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells.
Authors: Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, Monti E
Br J Cancer, 2014-05-22;110(12):2865-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma.
Authors: Wang, Lu-Kai, Hsiao, Tzu-Hung, Hong, Tse-Ming, Chen, Hsuan-Yu, Kao, Shih-Han, Wang, Wen-Lung, Yu, Sung-Lia, Lin, Ching-We, Yang, Pan-Chyr
PLoS ONE, 2014-05-09;9(5):e96765.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
Authors: Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B
Gene Ther, 2014-05-08;21(7):662-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Minimally invasive approach to the repair of injured skeletal muscle with a shape-memory scaffold.
Authors: Wang, Lin, Cao, Lan, Shansky, Janet, Wang, Zheng, Mooney, David, Vandenburgh, Herman
Mol Ther, 2014-04-28;22(8):1441-9.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
Authors: Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
Stem Cell Reports, 2014-04-24;2(5):648-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.
Authors: Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S
PLoS ONE, 2014-03-04;9(3):e89064.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer.
Authors: Rawnaq T, Dietrich L, Wolters-Eisfeld G, Uzunoglu F, Vashist Y, Bachmann K, Simon R, Izbicki J, Bockhorn M, Gungor C
Mol Cancer Res, 2014-02-24;12(5):670-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Authors: Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A
Cell Metab, 2014-02-04;19(2):209-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
Authors: Liang Z, Diepstra A, Xu C, van Imhoff G, Plattel W, Van Den Berg A, Visser L
PLoS ONE, 2014-01-28;9(1):e87474.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
Authors: Belzile, Jean-Phi, Stark, Thomas J, Yeo, Gene W, Spector, Deborah
J Virol, 2014-01-22;88(8):4021-39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway.
Authors: Shen X, Zhang Y, Feng Y, Zhang L, Li J, Xie Y, Luo X
Int J Oncol, 2014-01-08;44(3):791-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration.
Authors: Elloul, Sivan, Kedrin, Dmitriy, Knoblauch, Nicholas, Beck, Andrew H, Toker, Alex
Mol Cancer Res, 2013-11-22;12(3):464-76.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.
Authors: Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S
Elife, 2013-11-19;2(0):e00940.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of IGF-1 pathway in lung fibroblast activation.
Authors: Hung C, Rohani M, Lee S, Chen P, Schnapp L
Respir Res, 2013-10-08;14(0):102.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
Authors: Tucker, Budd A, Mullins, Robert F, Streb, Luan M, Anfinson, Kristin, Eyestone, Mari E, Kaalberg, Emily, Riker, Megan J, Drack, Arlene V, Braun, Terry A, Stone, Edwin M
Elife, 2013-08-27;2(0):e00824.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis.
Authors: Logan J, Sophocleous A, Marino S, Muir M, Brunton V, Idris A
J Bone Miner Res, 2013-05-01;28(5):1229-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
Authors: Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S
Nat Biotechnol, 2013-04-21;31(5):440-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
Stem Cells Transl Med, 2013-04-18;2(5):384-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Protein distribution during human erythroblast enucleation in vitro.
Authors: Bell A, Satchwell T, Heesom K, Hawley B, Kupzig S, Hazell M, Mushens R, Herman A, Toye A
PLoS ONE, 2013-04-02;8(4):e60300.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro.
Authors: Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C
BMC Cancer, 2013-04-01;13(0):170.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
Authors: Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M
J Cell Sci, 2013-02-26;126(0):1832-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation.
Authors: Tucker B, Anfinson K, Mullins R, Stone E, Young M
Stem Cells Transl Med, 2012-12-27;2(1):16-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells.
Authors: Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y
Mol Ther, 2012-11-27;21(1):228-39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems.
Authors: Aad, Pauline, Echternkamp, Sherrill, Sypherd, David D, Schreiber, Nicole B, Spicer, Leon J
Biol Reprod, 2012-10-04;87(4):79.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
Authors: Zelinka C, Scott M, Volkov L, Fischer A
PLoS ONE, 2012-09-04;7(9):e44477.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
Stem Cells, 2012-07-01;30(7):1455-64.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
Cell Transplant, 2011-12-21;21(6):1321-39.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase.
Authors: Laranjeira AB, de Vasconcellos JF, Sodek L, Spago MC, Fornazim MC, Tone LG, Brandalise SR, Nowill AE, Yunes JA
Leukemia, 2011-10-18;26(5):1001-11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.
Authors: Iozzo RV, Buraschi S, Genua M
J. Biol. Chem., 2011-08-12;286(40):34712-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-beta1 resulting in epithelial to mesenchymal transition.
Authors: Walsh L, Damjanovski S
Cell Commun Signal, 2011-05-02;9(1):10.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Muller glia.
Authors: Fischer AJ, Scott MA, Zelinka C, Sherwood P
Glia, 2010-04-15;58(6):633-49.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
Authors: Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G
Mol. Cancer Ther., 2010-03-02;9(3):706-17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Growth hormone promotes lymphangiogenesis.
Authors: Banziger-Tobler NE, Halin C, Kajiya K, Detmar M
Am. J. Pathol., 2008-06-26;173(2):586-97.
Applications: Western Blot

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
Cell Stem Cell, 2008-06-05;2(6):602-12.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas.
Authors: Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, Lee CT, Shinomura Y, Carbone DP, Imai K
Mol. Cancer Ther., 2008-06-01;7(6):1483-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Development and validation of sandwich ELISA microarrays with minimal assay interference.
Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
J. Proteome Res., 2008-04-19;7(6):2406-14.
Applications: ELISA (Standard)

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
J. Pathol., 2008-01-01;214(1):85-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
Authors: Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y
Mol. Biol. Cell, 2007-07-18;18(10):3764-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor.
Authors: Spicer LJ, Aad PY
Biol. Reprod., 2007-03-14;77(1):18-27.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat.
Authors: Sheen-Chen SM, Ho HT, Chia-Pei L, Hung KS, Eng HL
Dig. Dis. Sci., 2006-11-11;51(12):2220-4.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.
Authors: Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR
Am. J. Physiol. Heart Circ. Physiol., 2006-10-20;292(2):H1095-104.
Species: Canine, Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
Glia, 2006-06-01;53(8):845-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased extraocular muscle strength with direct injection of insulin-like growth factor-I.
Authors: Anderson BC, Christiansen SP, Grandt S, Grange RW, McLoon LK
Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2461-7.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
J. Invest. Dermatol., 2006-05-11;126(9):2096-105.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells.
Authors: Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ
J. Endocrinol., 2006-05-01;189(2):329-39.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.
Authors: Larsen PH, DaSilva AG, Conant K, Yong VW
J. Neurosci., 2006-02-22;26(8):2207-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Growth hormone-induced stimulation of multilineage human hematopoiesis.
Authors: Hanley MB, Napolitano LA, McCune JM
Stem Cells, 2005-06-13;23(8):1170-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Insulin growth factor-1 protects against excitotoxicity in the rat striatum.
Authors: Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E
Neuroreport, 2004-10-05;15(14):2251-4.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats.
Authors: Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G
Bone, 2004-05-01;34(5):862-8.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing.
Authors: Brenner N, Huning M, Stange R
Calcif. Tissue Int., 2004-04-01;74(4):388-97.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Improvement of the developmental capacity of oocytes from prepubertal cattle by intraovarian insulin-like growth factor-I application.
Authors: Oropeza A, Wrenzycki C, Herrmann D, Hadeler KG, Niemann H
Biol. Reprod., 2004-02-06;70(6):1634-43.
Species: Bovine
Sample Types: In Vivo
Applications: In Vivo

The effects of in ovo rhIGF-I administration on expression of the growth hormone secretagogue receptor (GHSR) during chicken embryonic development.
Authors: Gahr SA, Kocamis H, Richter JJ, Killefer J
Growth Dev Aging, 2004-01-01;68(1):3-10.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
Authors: Studer RK, Bergman R, Stubbs T, Decker K
Arthritis Res. Ther., 2003-11-07;6(1):R56-R64.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
Authors: Loeser RF, Carlson CS, Del Carlo M, Cole A
Arthritis Rheum., 2002-09-01;46(9):2349-57.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
Authors: Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC
Oncogene, 2002-08-22;21(37):5673-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Quantitative assessment of the integrity of the blood-retinal barrier in mice.
Authors: Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA
Invest. Ophthalmol. Vis. Sci., 2002-07-01;43(7):2462-7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
Authors: Loeser RF, 2018, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE
e0194453, 2000-09-01;43(9):2110-20.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli.
Authors: Deleu S, Pirson I, Clermont F, Nakamura T, Dumont JE, Maenhaut C
J. Cell. Physiol., 1999-11-01;181(2):342-54.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay