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Recombinant Human GPR37 Protein, CF

Catalog #: 9609-GP Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
9609-GP-050
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Summary Product Datasheets Carrier Free Reconstitution Calculator Background Related Research Areas

Recombinant Human GPR37 Protein, CF Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Bioassay data are not available.
Source
Chinese Hamster Ovary cell line, CHO-derived human GPR37 protein
Leu28-Met265, with a C-terminal 6-His tag
Accession #
O15354
N-terminal Sequence
Analysis
Leu28
Predicted Molecular Mass
26 kDa
SDS-PAGE
37-53 kDa, reducing conditions

Product Datasheets

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9609-GP

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

9609-GP

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: GPR37

GPR37 (G-protein coupled receptor 37), also called ETBR-LP-1 (endothelin B receptor-like protein 1) or PAELR (Parkin-associated endothelin receptor-like receptor) is a 587 aa, 7-transmembrane receptor for the neuroprotective and glioprotective factor prosaposin  (1, 4).  It is mainly expressed in neuronal cells, particularly in cerebellar Purkinje cells and the hippocampus (2). It is a substrate of the E3 ubiquitin ligase, parkin, which is up-regulated during endoplasmic reticulum stress (3). In a juvenile form of Parkinson's disease, GPR37 accumulates, contributing to stress-induced neuronal cell death (2). The  extracelluar domains (aa 27-265) of human and mouse GPR37 share 68% aa identity.

References
  1. Marazziti, D. et al. (1997) Genomics, 45:68.
  2. Donohue, P.J. et al. (1998) Brain Res Mol Brain Res. 54:152.
  3. Omura, T. et al. (2006) J Neurochem. 99:1456.
  4. Meyer, R.C. et al. (2013) Proc. Natl. Acad. Sci. U. S. A. 110: 9529
 
Long Name
G Protein-coupled Receptor 37
Entrez Gene IDs
2861 (Human); 14763 (Mouse); 117549 (Rat)
Alternate Names
EDNRBL; Endothelin B receptor-like protein 1; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); GPR37; hET(B)R-LP; PAELR; PAELRETBR-LP-1; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37

FAQs

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