Recombinant Cynomolgus Monkey Ly6E Fc Chimera Protein, CF

Recombinant Cynomolgus Monkey Ly6E Fc Chimera Protein, CF Summary

Product Specifications

Product Datasheets

Carrier Free

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

Background: Ly6E

Lymphocyte antigen 6E (Ly6E), also known as Stem cell antigen 2 (SCA-2) or Thymic shared antigen-1 (TSA-1), is a member of the lymphostromal cell membrane Ly6 protein superrfamily (1, 2). There are at least twenty different human Ly6 proteins that have been identified, and they are either secreted or GPI-anchor membrane-bound proteins (3). Cynomolgus Ly6E is synthesized as a precursor molecule that includes a signal peptide, a Ly6E chain, and a propeptide. Within the mature, main chain region, cynomolgus Ly6E shares 94% amino acid sequence identity with human Ly6E. Ly6E is involved in cell signalling transduction, cell adhesion, immune regulation and drug resistance, and is over-expressed in human malignancies, including head and neck squamous cell carcinomas and lung, and oesophageal cancers (4-7). Moreover, Ly6E over-expresses in gastric cancer cells, and is important for cell survival, proliferation and migration, and could be a novel oncogenic protein for efficient diagnosis and treatment of gastric cancer (2). LY6E has recently been shown to promote viral entry of some flaviviruses, including West Nile virus, Dengue virus, and Zika virus (8). Our in-house data indicate that Ly6E inhibits the human T cell activation, including IL-2, IFN-g secretions.