RCGD 423
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Description: gp130 modulator; activates JAK/STAT signaling
Chemical Name: N-(4-Bromophenyl)-4-phenyl-2-thiazolamine
Purity: ≥98%
Biological Activity
RCGD 423 is a gp130 modulator. Binds gp130, promotes Myc expression, increases lactate production and activates downstream JAK/STAT signaling pathways in hair follicle stem cells. Also increases articular chondrocyte activation and facilitates joint repair by regulating cartilage growth and differentiation.Technical Data
M.Wt:
331.23
Formula:
C15H11BrN2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
108237-91-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity.
Alam et al.
ACS Chem.Neurosci., 2018;9:462 -
Lactate dehydrogenase activity drives hair follicle stem cell activation.
Flores et al.
Nat.Cell Biol., 2017;19:1017
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