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Ranolazine dihydrochloride

Catalog #: 3118
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3118/50
Ranolazine dihydrochloride | CAS No. 95635-56-6 | Dehydrogenase Activators
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Description: Antianginal, activates pyruvate dehydrogenase
Alternative Names: RS 43285

Chemical Name: N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ranolazine dihydrochloride is an antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents.

Technical Data

M.Wt:
500.46
Formula:
C24H33N3O4.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
95635-56-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat.
    Zacharowski et al.
    Eur.J.Pharmacol., 2001;418:105
  2. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium.
    Shryock and Belardinelli
    Br.J.Pharmacol., 2008;153:1128
  3. Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.
    Wang et al.
    J.Pharmacol.Exp.Ther., 2008;325:875
  4. Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses.
    Helena Carstensen, Line Kjær, Maria Mathilde Haugaard, Mette Flethøj, Eva Zander Hesselkil, Jørgen K Kanters, Steen Pehrson, Rikke Buhl, Thomas Jespersen
    Journal of Cardiovascular Pharmacology, 2018;0(0):1533-4023.

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Citations for Ranolazine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Ranolazine dihydrochloride include:

3 Citations: Showing 1 - 3

  1. Effects of UK 68798 and RS 43285 on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation.
    Authors: Carstensen Et al.
    J Cardiovasc Electrophysiol  2019;30:596
  2. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  3. Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons.
    Authors: Park Et al.
    J Neurophysiol  2013;109:1378

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