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RA 839

Catalog #: 5707
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5707/10
5707/50
RA 839 | CAS No. 1832713-02-6 | Nrf2 Activators
1 Image
Description: Nrf2 activator; inhibits Nrf2/Keap1 interaction

Chemical Name: (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.

Technical Data

M.Wt:
452.57
Formula:
C25H28N2O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1832713-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for RA 839

The citations listed below are publications that use Tocris products. Selected citations for RA 839 include:

2 Citations: Showing 1 - 2

  1. A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy.
    Authors: Vladimir Et al.
    Redox Biol  2021;48:102186
  2. Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units.
    Authors: Rakesh Et al.
    Oxid Med Cell Longev  2020;2020:7289120

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