Home / ARF GTPase Inhibitors / QS 11

QS 11

Catalog #: 3324
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3324/10
3324/50
QS 11 | CAS No. 944328-88-5 | ARF GTPase Inhibitors
1 Image
Description: ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

Technical Data

M.Wt:
567.68
Formula:
C36H33N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
944328-88-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A chemical approach to stem cell biology
    Emre et al.
    Curr.Opin.Chem.Biol., 2007;11:252
  2. Small-molecule synergist of the Wnt/β-catenin signaling pathway.
    Zhang et al.
    Proc.Natl.Acad.Sci.USA, 2007;104:7444

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for QS 11

The citations listed below are publications that use Tocris products. Selected citations for QS 11 include:

2 Citations: Showing 1 - 2

  1. Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression.
    Authors: Gowda Et al.
    Mol Cell Biol  2018;38
  2. Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles
    Authors: Wu, J Et al.
    Scientific Reports  2016;6:29418

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for QS 11

There are currently no reviews for this product. Be the first to review QS 11 and earn rewards!

Have you used QS 11?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.