Home / Ubiquitin Ligase (E3) Inhibitors / PTC 209

PTC 209

Catalog #: 5191
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5191/10
5191/50
PTC 209 | CAS No. 315704-66-6 | Ubiquitin Ligase (E3) Inhibitors
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Description: Bmi-1 inhibitor; antitumor

Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PTC 209 is a Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.

Technical Data

M.Wt:
495.19
Formula:
C17H13Br2N5OS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
315704-66-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Self-renewal as a therapeutic target in human colorectal cancer.
    Kreso et al.
    Nat.Med., 2014;20:29

Product Datasheets

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Citations for PTC 209

The citations listed below are publications that use Tocris products. Selected citations for PTC 209 include:

2 Citations: Showing 1 - 2

  1. Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells.
    Authors: Zhaocheng Et al.
    Cell Death Dis  2021;12:644
  2. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.
    Authors: Yan Et al.
    Cancer Cell  2019;36:139-155.e10

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