PSB 12379
Chemical Name: N6-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
Purity: ≥98%
Biological Activity
PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cancer immunotherapy: selected targets and small-molecule modulators.
Weinmann
Chem.Med.Chem., 2016;11:450 -
α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors.
Bhattarai et al.
J.Med.Chem., 2015;58:6248
Product Datasheets
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Citations for PSB 12379
The citations listed below are publications that use Tocris products. Selected citations for PSB 12379 include:
2 Citations: Showing 1 - 2
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Microglial control of neuronal development via somatic purinergic junctions.
Authors: Istvan Et al.
Cell Rep 2022;40:111369
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Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition From Habitual to Goal-Directed Reward-Seeking Behavior.
Authors: Hyunjung Et al.
Biol Psychiatry 2020;88:797-808
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