PRT 4165

Catalog # Availability Size / Price Qty
5047/10
5047/50
PRT 4165 | CAS No. 31083-55-3 | Ubiquitin Ligase (E3) Inhibitors
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Description: Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); PRT 4165 inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. PRT 4165 prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). PRT 4165 inhibits the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. PRT 4165 blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro.

Technical Data

M.Wt:
235.24
Formula:
C15H9NO2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in 1eq. HCl with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
31083-55-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PRT 4165

The citations listed below are publications that use Tocris products. Selected citations for PRT 4165 include:

5 Citations: Showing 1 - 5

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