Home / Additional p53-related Compounds / PRIMA-1MET

PRIMA-1MET

Catalog #: 3710
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3710/10
PRIMA-1MET | CAS No. 5291-32-7 | Additional p53-related Compounds
1 Image
Description: Restores mutant p53 activity
Alternative Names: APR-246

Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

Technical Data

M.Wt:
199.25
Formula:
C10H17NO3
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
5291-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
    Aryee, D N T, Niedan, S, Ban, J, Schwentner, R, Muehlbacher, K, Kauer, M, Kofler, R, Kovar, H
    Br J Cancer, 2013;109(10):2696-704.
  2. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Robinson T, Liu J, Vizeacoumar F, Sun T, Maclean N, Egan S, Schimmer A, Datti A, Zacksenhaus E
    PLoS ONE, 2013;8(11):e78641.
  3. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
    Shen et al.
    Oncogene, 2008;27:6571
  4. PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.
    Stuber et al.
    Mol.Cancer, 2009;8:23
  5. PRIMA-1MET synergizes with cisp. to induce tumor cell apoptosis.
    Bykov et al.
    Oncogene, 2005;24:3484

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for PRIMA-1MET

The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1MET include:

3 Citations: Showing 1 - 3

  1. Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype.
    Authors: Katja Et al.
    Mol Cancer Ther  2022;21:1236-1245
  2. Estrogen Receptor-Beta2 (ERβ2)-Mutant p53-FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC).
    Authors: Kunle O Et al.
    Cancers (Basel)  2022;14
  3. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PRIMA-1MET

There are currently no reviews for this product. Be the first to review PRIMA-1MET and earn rewards!

Have you used PRIMA-1MET?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.