Pramlintide
Purity: ≥95%
Biological Activity
Pramlintide is a synthetic version of amylin (Cat. No. 3418). Exhibits high affinity for amylin, CGRP and calcitonin receptors (Ki values are 0.023, 3.8 and 5.1 nM respectively). Reduces postprandial hyperglycemia; also inhibits gastric emptying.Technical Data
(Modifications: Tyr-37 = C-terminal amide, Disulfide bridge: 2-7)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pramlintide, the synthetic analogue of amylin: phsyiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk.
Hoogwerf et al.
Vasc.Health Risk Manag., 2008;4:355 -
Preclinical pharmacology of pramli. in the rat: comparisons with human and rat amylin.
Young et al.
Drug Dev.Res., 1996;37:231 -
Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy
MS Al-Keilani, DH Alsmadi, RS Darweesh, KH Alzoubi
Clin Pharmacol, 2018;10(0):23-29.
Product Datasheets
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Citation for Pramlintide
The citations listed below are publications that use Tocris products. Selected citations for Pramlintide include:
1 Citation: Showing 1 - 1
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Area Postrema Cell Types that Mediate Nausea-Associated Behaviors.
Authors: Stephen D Et al.
Neuron 2021;109:461-472.e5
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