PR 619
Chemical Name: 2,6-Diamino-3,5-dithiocyanopyridine
Purity: ≥98%
Biological Activity
PR 619 is a broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun et al.
Chem.Biol., 2011;18:1401 -
The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases.
Seiberlich et al.
Biochim.Biophys.Acta, 2012;1823:2057
Product Datasheets
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Citations for PR 619
The citations listed below are publications that use Tocris products. Selected citations for PR 619 include:
2 Citations: Showing 1 - 2
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The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Authors: Saldate Et al.
J Biol Chem 2018;293:2232
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A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.
Authors: JoAnn Et al.
Cell Rep 2018;24:3312-3323.e5
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