PQ 401

Catalog #: 2768
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
2768/10
2768/50

PQ 401 | CAS No. 196868-63-0 | Insulin and Insulin-like Receptor Inhibitors

1 Image

Description: IGF1R inhibitor

Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea

Purity: ≥99%

View All Products for Insulin and Insulin-like Receptor Inhibitors

Product Details

Citations (5)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC₅₀ value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.

Technical Data

M.Wt:

341.79

Formula:

C₁₈H₁₆ClN₃O₂

Solubility:

Soluble to 50 mM in DMSO and to 25 mM in ethanol

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

196868-63-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor.
Anderson et al.
J.Comb.Chem., 2006;8:784
The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus
W Kim, G Zou, W Pan, N Fricke, HA Faizi, SM Kim, R Khader, S Li, K Lee, I Escorba, PM Vlahovska, H Gao, FM Ausubel, E Mylonakis
MBio, 2020;11(3):.

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for PQ 401

The citations listed below are publications that use Tocris products. Selected citations for PQ 401 include:

5 Citations: Showing 1 - 5

Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
Ins-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.
Authors: Shen Et al.
Mol Cell Biol 2012;32:4116
Ins-like growth factor 1-mediated hyperthermia involves anterior hypothalamic Ins receptors.
Authors: Sanchez-Alavez Et al.
J Biol Chem 2011;286:14983
Activation of the Ins-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells.
Authors: Jameson Et al.
Mol Cancer Ther 2011;10:2124
Ins-like growth factor-I-stimulated Ins receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.
Authors: Radhakrishnan Et al.
J Biol Chem 2010;285:15682

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PQ 401

There are currently no reviews for this product. Be the first to review PQ 401 and earn rewards!

Have you used PQ 401?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.