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PP 3

Catalog #: 2794
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2794/10
PP 3 | CAS No. 5334-30-5 | Src Family Kinase Inhibitors
1 Image
Description: Negative control for PP 2 (Cat. No. 1407)

Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥98%

Product Details
Citations (7)
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Biological Activity

PP 3 is a negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).

Active Analog also available.

Technical Data

M.Wt:
211.22
Formula:
C11H9N5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
5334-30-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

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Citations for PP 3

The citations listed below are publications that use Tocris products. Selected citations for PP 3 include:

7 Citations: Showing 1 - 7

  1. Mathematical model of early Reelin-induced Src family kinase-mediated signaling.
    Authors: Hass Et al.
    PLoS One  2017;12:e0186927
  2. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
    Authors: Li Et al.
    J Clin Invest  2016;126:389
  3. Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.
    Authors: Vijayakumar Et al.
    Neural Regen Res  2015;128:251
  4. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  5. Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue.
    Authors: Rosas Et al.
    Cell  2014;9:2164
  6. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
    Authors: Chen Et al.
    Eur J Neurosci  2014;39:1439
  7. Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
    Authors: Kupferman Et al.
    J Neuroimmune Pharmacol  2014;158:1335

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