PND 1186
Chemical Name: 2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide
Purity: ≥98%
Biological Activity
PND 1186 is a potent FAK inhibitor (IC50 values are 1.5 and 100 nM for recombinant FAK and FAK in breast carcinoma cells, respectively). Promotes caspase activation; triggering apoptosis. Inhibits 4T1 breast carcinoma subcutaneous tumor growth and breast carcinoma cell motility. Decreases spontaneous breast to lung metastasis in pre-clinical models. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.
Walsh et al.
Cancer Biol.Ther., 2010;9:778 -
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.
Tanjoni et al.
Cancer Biol.Ther., 2010;9:764 -
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
Jiang et al.
Nat.Med., 2016;22:851
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