PKI (5-24)
Purity: ≥95%
Biological Activity
PKI (5-24) is a high affinity PKA inhibitor (Ki = 2.3 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.
Cheng et al.
J.Biol.Chem., 1986;261:989 -
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Narayana et al.
Biochemistry, 1997;36:4438
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Citations for PKI (5-24)
The citations listed below are publications that use Tocris products. Selected citations for PKI (5-24) include:
3 Citations: Showing 1 - 3
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HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum.
Authors: Fuqin Et al.
J Physiol 2022;600:4917-4938
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Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway.
Authors: Ruihua Et al.
Int J Ophthalmol 2020;13:552-559
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Activation of β2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of rats.
Authors: Zhou Et al.
Learn Mem 2013;20:274
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