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Photo-lenalidomide-acid

Catalog #: 7328 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7328/50
Photo-lenalidomide-acid | CAS No. 2363154-39-4 | Degrader Building Blocks
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Description: Functionalized photoswitchable cereblon ligand for Degraders

Chemical Name: (E)-2-(4-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)diazenyl)-2,6-dimethoxyphenoxy)acetic acid

Purity: ≥95%

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Biological Activity

Photo-lenalidomide-acid is a functionalized cereblon ligand containing a dimethoxy azo-benzene photoswitch; for use as a precursor to photoswitchable Degraders (PHOTACs). Photo-lenalidomide-acid is supplied with a carboxylic acid functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for Degrader R&D.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
482.45
Formula:
C23H22N4O8
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2363154-39-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PHOTACs enable optical control of protein degradation.
    Reynders et al.
    Sci.Adv., 2020;6:eaay5064

Product Datasheets

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