PhiKan 083
Discontinued Product
Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
Purity: ≥99%
Biological Activity
PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
Boeckler et al.
Proc.Natl.Acad.Sci., 2008;105:10360 -
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient.
Wiman
Oncogene., 2010;29:4245
Product Datasheets
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Citation for PhiKan 083
The citations listed below are publications that use Tocris products. Selected citations for PhiKan 083 include:
1 Citation: Showing 1 - 1
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Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.
Authors: Soares Et al.
Oncotarget 2016;7:4326
FAQs
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