PF 543 hydrochloride

Discontinued Product

5754 has been discontinued.
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PF 543 hydrochloride | CAS No. 1706522-79-3 | Sphingosine Kinase Inhibitors
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Description: Potent and selective SphK1 inhibitor

Chemical Name: (2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

PF 543 hydrochloride is a potent and selective SphK1 inhibitor (IC50 = 2 nM; Ki = 3.6 nM). Exhibits >100-fold selectivity for Sphk1 over Sphk2. Also exhibits >5,000 fold selectivity over S1P1-5 receptors and 48 protein and lipid kinases. Inhibits growth and metastasis of several types of cancer cell including ovarian, colorectal and breast cancers, and suppresses HCT-116 tumor xenograft growth in mice. Antifibrotic and anti-inflammatory in a range of in vivo disease models. Also reduces sickling, hemolysis and inflammation in a transgenic mouse model of sickle cell disease.

Technical Data

M.Wt:
502.07
Formula:
C27H31NO4S.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1706522-79-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 543 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PF 543 hydrochloride include:

2 Citations: Showing 1 - 2

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