PF 06409577
Chemical Name: 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
Purity: ≥98%
Biological Activity
PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Selective activation of AMPK β1-containing isoforms improves kidney function in a rat model of diabetic nephropathy.
Salatto et al.
J.Pharmacol.Exp.Ther., 2017;361:303 -
Discovery and preclinical characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a direct activator of adenosine monophosphate-activated protein kinase (AMPK), for the potential treatment of diab
Cameron et al.
J.Med.Chem., 2016;59:8068
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Citation for PF 06409577
The citations listed below are publications that use Tocris products. Selected citations for PF 06409577 include:
1 Citation: Showing 1 - 1
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An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.
Authors: Smith Et al.
Nat Commun 2019;10:2901
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